PPIRE07554
Target Protein Information
| Protein_Name | Cyclin-A2 |
|---|---|
| Protein_Sequence | MLGNSAPGPATREAGSALLALQQTALQEDQENINPEKAAPVQQPRTRAALAVLKSGNPRGLAQQQRPKTRRVAPLKDLPVNDEHVTVPPWKANSKQPAFTIHVDEAEKEAQKKPAESQKIEREDALAFNSAISLPGPRKPLVPLDYPMDGSFESPHTMDMSIILEDEKPVSVNEVPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKYHGVSLLNPPETLNL |
| Organism_Source | Homo sapiens |
| Functional_Classification | cyclins |
| Cellular_Localization | Nucleus |
| Gene_Names | CCNA2 |
| UniProt_ID | P20248 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | ORC1233-240 |
|---|---|
| Peptide_Sequence | ARKRLELG |
| Peptide_Length | 8 |
| Peptide_SMILES | CC(C)C[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)N)C(=O)NCC(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 942.13 |
|---|---|
| Aliphatic_Index | 110.00000 |
| Aromaticity | 0.00000 |
| Average_Rotatable_Bonds | 4.25000 |
| Charge_at_pH_7 | 1.99946 |
| Isoelectric_Point | 11.47970 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 13 |
| Number_of_Hydrogen_Bond_Donors | 17 |
| Topological_Polar_Surface_Area | 454.14000 |
| X_logP_energy | -3.94426 |
Interaction Information
| Affinity | KD=0.63 uM |
|---|---|
| Affinity_Assay | Isothermal titration calorimetry |
| PDB_ID | 6P3W |
| Type | Inhibitor |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Structural basis for the ORC1-Cyclin A association. |
| Release_Year | 2019 |
| PMID | 31309634 |
| DOI | 10.1002/pro.3689 |