PPIRE07558

Target Protein Information
Protein_Name C3a anaphylatoxin chemotactic receptor
Protein_Sequence MESSSAETNSTGLHLEPQYQPETILAMAILGLTFVLGLPGNGLVLWVAGLKMRRTVNTVWFLHLTVADFVCCLSLPFSMAHLALRGYWPYGEILCKFIPTVIIFNMFASVFLLTAISLDRCLMVLKPIWCQNHRNVRTACIICGCIWLVAFVLCIPVFVYRETFTLENHTICTYNFSPGSFDYLDYAYDRDAWGYGTPDPIVQLPGEMEHRSDPSSFQTQDGPWSVTTTLYSQTSQRPSEDSFHMDSAKLSGQGKYVDVVLPTNLCGLPMEENRTNTLHNAAFLSSDLDVSNATQKCLSTPEPPQDFWDDLSPFTHEYRTPRLLKVITFTRLVVGFLLPMIIMVACYTLIIFRMRRVRVVKSWNKALHLAMVVVTIFLICWAPYHVFGVLILFINPESRVGAALLSWDHVSIALASANSCFNPFLYALLGRDLRKRVRQSMKGILEAAFSEDISKSTSFIQAKAFSEKHSLSTNV
Organism_Source Cavia porcellus
Functional_Classification G protein-coupled receptor
Cellular_Localization Plasma membrane
Gene_Names C3AR1
UniProt_ID O88680
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name C3a(70-77)
Peptide_Sequence ASHLGLAR
Peptide_Length 8
Peptide_SMILES CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CO)NC(=O)[C@H](C)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 823.95
Aliphatic_Index 122.50000
Aromaticity 0.00000
Average_Rotatable_Bonds 3.25000
Charge_at_pH_7 1.08889
Isoelectric_Point 10.55176
Number_of_Hydrogen_Bond_Acceptors 12
Number_of_Hydrogen_Bond_Donors 14
Topological_Polar_Surface_Area 377.83000
X_logP_energy -4.22333
Interaction Information
Affinity IC50=6.8 uM
Affinity_Assay radioreceptor assay
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Research Articles
Title Studies on the ileum-contracting mechanisms and identification as a complement C3a receptor agonist of oryzatensin, a bioactive peptide derived from rice albumin.
Release_Year 1996
PMID 8822503
DOI 10.1016/0196-9781(95)02059-4