PPIRE07580

Target Protein Information
Protein_Name Alpha-2A adrenergic receptor
Protein_Sequence MGSLQPDAGNGSWNGSEAPGGGARASPYSLQVTLTLVCLAGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGQAWCEIYLALDMLFCTSSIAHLCAISLDRHWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIERKGGGGGGGRQRCEINDHKWYVIASCTGSFFVPCLIMILVYVRIYQIAKRRTRVPPSRRVRTPPPPPPPPPPPPRQPGPPSAGLMAWAPERGAGSASAETEPLPTQLNGAAGEPAAAGPRETDALDLEESSSSEHAERPPGPASRGPRQGPSEPGEARGQHPSARARDRGARGVGGRARGDTPEAPRRLWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAVGCSVPPTLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV
Organism_Source Oryctolagus cuniculus
Functional_Classification G protein-coupled receptor
Cellular_Localization Plasma membrane
Gene_Names adra2A
UniProt_ID Q5ZQK3
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name BB octapeptide
Peptide_Sequence DPDADILQ
Peptide_Length 8
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 885.93
Aliphatic_Index 110.00000
Aromaticity 0.00000
Average_Rotatable_Bonds 3.37500
Charge_at_pH_7 -3.00068
Isoelectric_Point 3.33853
Number_of_Hydrogen_Bond_Acceptors 13
Number_of_Hydrogen_Bond_Donors 12
Topological_Polar_Surface_Area 413.22000
X_logP_energy -3.90020
Interaction Information
Affinity IC50=104.5 uM
Affinity_Assay platelet aggregation assay
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title A novel peptide inhibitor of platelet aggregation from stiff silkworm, Bombyx batryticatus.
Release_Year 2013
PMID 24361453
DOI 10.1016/j.peptides.2013.12.004