PPIRE07595

Target Protein Information
Protein_Name Heat shock protein STI1
Protein_Sequence MSLTADEYKQQGNAAFTAKDYDKAIELFTKAIEVSETPNHVLYSNRSACYTSLKKFSDALNDANECVKINPSWSKGYNRLGAAHLGLGDLDEAESNYKKALELDASNKAAKEGLDQVHRTQQARQAQPDLGLTQLFADPNLIENLKKNPKTSEMMKDPQLVAKLIGYKQNPQAIGQDLFTDPRLMTIMATLMGVDLNMDDINQSNSMPKEPETSKSTEQKKDAEPQSDSTTSKENSSKAPQKEESKESEPMEVDEDDSKIEADKEKAEGNKFYKARQFDEAIEHYNKAWELHKDITYLNNRAAAEYEKGEYETAISTLNDAVEQGREMRADYKVISKSFARIGNAYHKLGDLKKTIEYYQKSLTEHRTADILTKLRNAEKELKKAEAEAYVNPEKAEEARLEGKEYFTKSDWPNAVKAYTEMIKRAPEDARGYSNRAAALAKLMSFPEAIADCNKAIEKDPNFVRAYIRKATAQIAVKEYASALETLDAARTKDAEVNNGSSAREIDQLYYKASQQRFQPGTSNETPEETYQRAMKDPEVAAIMQDPVMQSILQQAQQNPAALQEHMKNPEVFKKIQTLIAAGIIRTGR
Organism_Source Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Functional_Classification co-chaperones
Cellular_Localization Cytoplasm
Gene_Names STI1
UniProt_ID P15705
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name yHsp90 peptide DTEMEEVD
Peptide_Sequence DTEMEEVD
Peptide_Length 8
Peptide_SMILES CSCC[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC(=O)O)[C@@H](C)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)O)C(C)C
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 966.97
Aliphatic_Index 36.25000
Aromaticity 0.00000
Average_Rotatable_Bonds 4.12500
Charge_at_pH_7 -4.99580
Isoelectric_Point 3.22578
Number_of_Hydrogen_Bond_Acceptors 16
Number_of_Hydrogen_Bond_Donors 15
Topological_Polar_Surface_Area 473.75000
X_logP_energy -4.87440
Interaction Information
Affinity KD=0.3 mM
Affinity_Assay Isothermal titration calorimetry
PDB_ID 3UQ3
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title The architecture of functional modules in the Hsp90 co-chaperone Sti1/Hop.
Release_Year 2012
PMID 22227520
DOI 10.1038/emboj.2011.472