PPIRE07639

Target Protein Information
Protein_Name H-2 class I histocompatibility antigen, K-Q alpha chain
Protein_Sequence PRFISVGYVDDTELVRFDSDAENPRYEPRARWMEQVEPEYWERNTQIAKDNEQSSRVDLRTLLRYYNQSAGGSHTIQRMYGCDVGSDGRLLRGYEQVAYDGCDYIALNEDLKTWTAADMAALITKHKWEQAGAAERRRAYLEGACVEWLSRHLKNGNATLLRTDSPKAHVTHHSRPEDKVTLRCWALGFYPADITLTWQLNGEELTQDMELVETRPAGDGTFQKWASVVVPLGKEQYYTCHVYHQGLPKPLTLRWEPPPSAVSNTVIIAVLVVLGAAIVTGAVVAFVMMRRRNTGGKGGDYALAPGSQTSDLSLPDCKVMVHDPHSLA
Organism_Source Mus musculus
Functional_Classification MHC class I molecules
Cellular_Localization Plasma membrane
Gene_Names H2-K1
UniProt_ID P14428
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name dEV8
Peptide_Sequence EXXKFYSV
Peptide_Length 8
Peptide_SMILES CC(C)[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)CNC(=O)[C@@H](N)CCC(=O)O)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 885.97
Aliphatic_Index 36.25000
Aromaticity 0.25000
Average_Rotatable_Bonds 3.50000
Charge_at_pH_7 -0.00139
Isoelectric_Point 6.40200
Number_of_Hydrogen_Bond_Acceptors 13
Number_of_Hydrogen_Bond_Donors 13
Topological_Polar_Surface_Area 370.80000
X_logP_energy -3.11220
Interaction Information
Affinity KD=90.1 nM
Affinity_Assay competitive radioligand binding assay
PDB_ID 1LEG
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Structural comparison of allogeneic and syngeneic T cell receptor-peptide-major histocompatibility complex complexes: a buried alloreactive mutation subtly alters peptide presentation substantially increasing V(beta)Interactions.
Release_Year 2002
PMID 11994422
DOI 10.1084/jem.20011644