PPIRE07672

Target Protein Information
Protein_Name Pancreatic triacylglycerol lipase
Protein_Sequence SEVCFPRLGCFSDDAPWAGIVQRPLKILPWSPKDVDTRFLLYTNQNQNNYQELVADPSTITNSNFRMDRKTRFIIHGFIDKGEEDWLSNICKNLFKVESVNCICVDWKGGSRTGYTQASQNIRIVGAEVAYFVEVLKSSLGYSPSNVHVIGHSLGSHAAGEAGRRTNGTIERITGLDPAEPCFQGTPELVRLDPSDAKFVDVIHTDAAPIIPNLGFGMSQTVGHLDFFPNGGKQMPGCQKNILSQIVDIDGIWEGTRDFVACNHLRSYKYYADSILNPDGFAGFPCDSYNVFTANKCFPCPSEGCPQMGHYADRFPGKTNGVSQVFYLNTGDASNFARWRYKVSVTLSGKKVTGHILVSLFGNEGNSRQYEIYKGTLQPDNTHSDEFDSDVEVGDLQKVKFIWYNNNVINPTLPRVGASKITVERNDGKVYDFCSQETVREEVLLTLNPC
Organism_Source Sus scrofa
Functional_Classification lipases
Cellular_Localization Extracellular
Gene_Names PNLIP
UniProt_ID P00591
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name FYLGYCDY
Peptide_Sequence FYLGYCDY
Peptide_Length 8
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)Cc1ccccc1)C(=O)NCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1043.16
Aliphatic_Index 48.75000
Aromaticity 0.50000
Average_Rotatable_Bonds 3.50000
Charge_at_pH_7 -1.06610
Isoelectric_Point 3.74997
Number_of_Hydrogen_Bond_Acceptors 14
Number_of_Hydrogen_Bond_Donors 14
Topological_Polar_Surface_Area 365.01000
X_logP_energy -0.03850
Interaction Information
Affinity IC50=0.47 mM
Affinity_Assay Enzyme Inhibition Kinetics
PDB_ID 1ETH
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title An in vitro study of lipase inhibitory peptides obtained from de-oiled rice bran.
Release_Year 2021
PMID 35478653
DOI 10.1039/d1ra01411k