PPIRE07703

Target Protein Information
Protein_Name Heat shock protein STI1
Protein_Sequence MSLTADEYKQQGNAAFTAKDYDKAIELFTKAIEVSETPNHVLYSNRSACYTSLKKFSDALNDANECVKINPSWSKGYNRLGAAHLGLGDLDEAESNYKKALELDASNKAAKEGLDQVHRTQQARQAQPDLGLTQLFADPNLIENLKKNPKTSEMMKDPQLVAKLIGYKQNPQAIGQDLFTDPRLMTIMATLMGVDLNMDDINQSNSMPKEPETSKSTEQKKDAEPQSDSTTSKENSSKAPQKEESKESEPMEVDEDDSKIEADKEKAEGNKFYKARQFDEAIEHYNKAWELHKDITYLNNRAAAEYEKGEYETAISTLNDAVEQGREMRADYKVISKSFARIGNAYHKLGDLKKTIEYYQKSLTEHRTADILTKLRNAEKELKKAEAEAYVNPEKAEEARLEGKEYFTKSDWPNAVKAYTEMIKRAPEDARGYSNRAAALAKLMSFPEAIADCNKAIEKDPNFVRAYIRKATAQIAVKEYASALETLDAARTKDAEVNNGSSAREIDQLYYKASQQRFQPGTSNETPEETYQRAMKDPEVAAIMQDPVMQSILQQAQQNPAALQEHMKNPEVFKKIQTLIAAGIIRTGR
Organism_Source Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Functional_Classification co-chaperones
Cellular_Localization Cytoplasm
Gene_Names STI1
UniProt_ID P15705
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name yHsp90 peptide GPTVEEVD
Peptide_Sequence GPTVEEVD
Peptide_Length 8
Peptide_SMILES CC(C)[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)CN)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 844.87
Aliphatic_Index 72.50000
Aromaticity 0.00000
Average_Rotatable_Bonds 3.12500
Charge_at_pH_7 -2.99802
Isoelectric_Point 3.42471
Number_of_Hydrogen_Bond_Acceptors 13
Number_of_Hydrogen_Bond_Donors 12
Topological_Polar_Surface_Area 390.36000
X_logP_energy -4.17340
Interaction Information
Affinity KD=37 mM
Affinity_Assay Isothermal titration calorimetry
PDB_ID 3UQ3
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title The architecture of functional modules in the Hsp90 co-chaperone Sti1/Hop.
Release_Year 2012
PMID 22227520
DOI 10.1038/emboj.2011.472