PPIRE07713
Target Protein Information
| Protein_Name | SCRIB overlapping open reading frame protein |
|---|---|
| Protein_Sequence | MRTEPRPPAPSPPSAAAGARAAHPHHAQVHPAVALQPARGVGGQAALFAAGRAGGDLPLQPQPGGAAARRQPAARAAQAFFPAAELAQAGPERQRDPAVASRGGQLHAAGGAGRVPERYP |
| Organism_Source | Homo sapiens |
| Functional_Classification | PDZ domain scaffold |
| Cellular_Localization | Plasma membrane |
| Gene_Names | SCRIB |
| UniProt_ID | C0HLS1 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | APC PBM peptide |
|---|---|
| Peptide_Sequence | GSYLVTSV |
| Peptide_Length | 8 |
| Peptide_SMILES | CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)O)C(C)C)[C@@H](C)O)C(C)C |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 824.93 |
|---|---|
| Aliphatic_Index | 121.25000 |
| Aromaticity | 0.12500 |
| Average_Rotatable_Bonds | 3.00000 |
| Charge_at_pH_7 | -0.00287 |
| Isoelectric_Point | 6.09320 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 13 |
| Number_of_Hydrogen_Bond_Donors | 13 |
| Topological_Polar_Surface_Area | 347.94000 |
| X_logP_energy | -3.90490 |
Interaction Information
| Affinity | KD=18.8 uM |
|---|---|
| Affinity_Assay | Isothermal titration calorimetry |
| PDB_ID | None |
| Type | Affinity ligand |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Crystal structure of the human Scribble PDZ1 domain bound to the PDZ-binding motif of APC. |
| Release_Year | 2019 |
| PMID | 30659601 |
| DOI | 10.1002/1873-3468.13329 |