PPIRE07737
Target Protein Information
| Protein_Name | Telomeric repeat-binding factor 1 |
|---|---|
| Protein_Sequence | MAEDVSSAAPSPRGCADGRDADPTEEQMAETERNDEEQFECQELLECQVQVGAPEEEEEEEEDAGLVAEAEAVAAGWMLDFLCLSLCRAFRDGRSEDFRRTRNSAEAIIHGLSSLTACQLRTIYICQFLTRIAAGKTLDAQFENDERITPLESALMIWGSIEKEHDKLHEEIQNLIKIQAIAVCMENGNFKEAEEVFERIFGDPNSHMPFKSKLLMIISQKDTFHSFFQHFSYNHMMEKIKSYVNYVLSEKSSTFLMKAAAKVVESKRTRTITSQDKPSGNDVEMETEANLDTRKSVSDKQSAVTESSEGTVSLLRSHKNLFLSKLQHGTQQQDLNKKERRVGTPQSTKKKKESRRATESRIPVSKSQPVTPEKHRARKRQAWLWEEDKNLRSGVRKYGEGNWSKILLHYKFNNRTSVMLKDRWRTMKKLKLISSDSED |
| Organism_Source | Homo sapiens |
| Functional_Classification | telomere-binding proteins |
| Cellular_Localization | Nucleus |
| Gene_Names | TERF1 |
| UniProt_ID | P54274 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | TERB1TBM |
|---|---|
| Peptide_Sequence | ILLTPRRR |
| Peptide_Length | 8 |
| Peptide_SMILES | CC[C@H](C)[C@H](N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)[C@@H](C)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
|
|
|
Peptide Physicochemical
| Molecular_Weight | 1024.28 |
|---|---|
| Aliphatic_Index | 146.25000 |
| Aromaticity | 0.00000 |
| Average_Rotatable_Bonds | 4.12500 |
| Charge_at_pH_7 | 2.99797 |
| Isoelectric_Point | 12.80107 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 13 |
| Number_of_Hydrogen_Bond_Donors | 18 |
| Topological_Polar_Surface_Area | 464.16000 |
| X_logP_energy | -3.39299 |
Interaction Information
| Affinity | KD=75.1 nM |
|---|---|
| Affinity_Assay | flow cytometry protein interaction assay |
| PDB_ID | 5WIR |
| Type | Affinity ligand |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Dissecting the telomere-inner nuclear membrane interface formed in meiosis. |
| Release_Year | 2017 |
| PMID | 29083414 |
| DOI | 10.1038/nsmb.3493 |