PPIRE07812

Target Protein Information
Protein_Name Angiotensin-converting enzyme
Protein_Sequence MGAAPGRPGRGPLPLPLPLLLLLPLLLPPPPPPAALALDPELQPGNFAADEAGAQLFVQSFNSSAELVMYQSTVASWAYDTNITEENARRQEEAALLNQEFAEVWGQKAKELYDPIWQNFSDPVLRRVISGVRTLGPANLPVEKRQQYNALLSNMNRIYSTARVCFYPNKTAICWSLDPELTHIMAISRNYALLLYAWEGWHNAVGTPLKPLYQNFTVLSNEAYQKDGFSDTGAYWRSWYESPTFVEDLEHLYHQVEPLYLNLHAYVRRALHRRYGDRYINLRGPIPAHLLGDMWAQSWDNLYDMMVPFPDKPSLDVTSTMVRKGWNTTHMFRVAEEFFTSLGLSPMPPEFWAGSMLEKPTDGREVVCHASAWDFYNRRDFRIKQCTRVTMDQLSTVHHEMGHVQYYLQYKEQPVSLRQGANPGFHEAIGDVLALSVSTPAHLYKIGLLDNVSNDIESDINFLLKMALEKIAFLPFGYLVDQWRWGVFSGRTPPSRYNFDWWYLRTKYQGICPPVARNETHFDAGAKFHVPNVTPYIRYFVSFVLQFQFHQALCKEAGHQGPLHTCDIYQSTQAGAKLREALRAGSSRPWQDVLREAIGSDTLDAQPLLDYFQPVSRWLQEQNKRNGEVLGWPEYQWRPPMPNNYPQDIGLVTDEVEARRFVEEYDRRSLVIWNEYAEANWNYNTNITTETSKILLQKNIQMANHTFKFGTWARQFDVTNFQNASIKRMIKKIQDLERAALPAKELEEYNKILLDMETTYSVASVCHTNGTCLQLEPDLTNLMATSRKYEDLLWAWKSWREKVGRAILPFFPKYVELANKAARLNGYEDAGDSWRAMYEMPSLEQDLEQLYQELQPLYLNLHAYVRRALHRHYGPQHINLEGPIPAHLLGNMWAQSWVNILDLVLPFPKKPPEDITKIMKSQHWKPSKMFEEAEKFFTSLGMLSTPPSFWKNSMMERPADGREVECHASAWDFYNGRDFRIKKCTEVTVEDLLSIFHQMGHIQYFLQYRNLSVIFRAGANPAFEEAVGSVITLSASSHKHLLNRGLLSHQHQDSEEEVNFLMSVALEKIAFIPFSYLMDLFRWKVFDGTIQKNVYNQEWWNLRLKYQGLCPPIPRTEEDFDPGAKFHISASVPYLRYFLSLVLQFQFHESLCKASGHIGPLHRCDIYNSKKAGKLLEDVLKLGSSKPWPEVLQKITGQTQMSTKALMTYFKPLLNWLVTENVRQGEILGWPDFSCTFEEKDTEKVAFLNLELDPDQAKYGQWVLLALSFIMFLAALLLAYRLYFLEKKSLPQATNAPATEAQASGSRDTSAPETQPKAYFLGIAMDPRLVAKRQWILLSLCLILMLCSISLTIRVFMQHYKKPPWMRAEWWSWD
Organism_Source Canis lupus familiaris
Functional_Classification peptidases
Cellular_Localization Plasma membrane
Gene_Names ACE
UniProt_ID A0A8P0TQ57
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name ACTH 4-11
Peptide_Sequence MEHFRWGK
Peptide_Length 8
Peptide_SMILES CSCC[C@H](N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1090.27
Aliphatic_Index 0.00000
Aromaticity 0.25000
Average_Rotatable_Bonds 4.37500
Charge_at_pH_7 1.09037
Isoelectric_Point 9.69703
Number_of_Hydrogen_Bond_Acceptors 14
Number_of_Hydrogen_Bond_Donors 16
Topological_Polar_Surface_Area 436.71000
X_logP_energy -1.63403
Interaction Information
Affinity IC50=24 uM
Affinity_Assay Enzyme Inhibition Kinetics
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Inhibition of canine lung angiotensin converting enzyme by ACTH and structurally related peptides.
Release_Year 1982
PMID 6280715
DOI 10.1016/0006-291x(82)91418-8