PPIRE07838
Target Protein Information
| Protein_Name | SCRIB overlapping open reading frame protein |
|---|---|
| Protein_Sequence | MRTEPRPPAPSPPSAAAGARAAHPHHAQVHPAVALQPARGVGGQAALFAAGRAGGDLPLQPQPGGAAARRQPAARAAQAFFPAAELAQAGPERQRDPAVASRGGQLHAAGGAGRVPERYP |
| Organism_Source | Homo sapiens |
| Functional_Classification | PDZ domain |
| Cellular_Localization | Cytoplasm |
| Gene_Names | SCRIB |
| UniProt_ID | C0HLS1 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | b-PIX PBM peptide |
|---|---|
| Peptide_Sequence | PAWDETNL |
| Peptide_Length | 8 |
| Peptide_SMILES | CC(C)C[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1)[C@@H](C)O)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 945.00 |
|---|---|
| Aliphatic_Index | 61.25000 |
| Aromaticity | 0.12500 |
| Average_Rotatable_Bonds | 3.37500 |
| Charge_at_pH_7 | -1.99979 |
| Isoelectric_Point | 3.55007 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 13 |
| Number_of_Hydrogen_Bond_Donors | 14 |
| Topological_Polar_Surface_Area | 406.74000 |
| X_logP_energy | -3.39770 |
Interaction Information
| Affinity | KD=67.8 uM |
|---|---|
| Affinity_Assay | Isothermal titration calorimetry |
| PDB_ID | None |
| Type | Affinity ligand |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Structural basis for the differential interaction of Scribble PDZ domains with the guanine nucleotide exchange factor Beta-PIX. |
| Release_Year | 2017 |
| PMID | 29061852 |
| DOI | 10.1074/jbc.M117.799452 |