PPIRE07877

Target Protein Information
Protein_Name Sorting nexin-27
Protein_Sequence MADEDGEGIHPSAPHRNGGGGGGGGSGLHCAGNGGGGGGGPRVVRIVKSESGYGFNVRGQVSEGGQLRSINGELYAPLQHVSAVLPGGAADRAGVRKGDRILEVNHVNVEGATHKQVVDLIRAGEKELILTVLSVPPHEADNLDPSDDSLGQSFYDYTEKQAVPISVPRYKHVEQNGEKFVVYNVYMAGRQLCSKRYREFAILHQNLKREFANFTFPRLPGKWPFSLSEQQLDARRRGLEEYLEKVCSIRVIGESDIMQEFLSESDENYNGVSDVELRVALPDGTTVTVRVKKNSTTDQVYQAIAAKVGMDSTTVNYFALFEVISHSFVRKLAPNEFPHKLYIQNYTSAVPGTCLTIRKWLFTTEEEILLNDNDLAVTYFFHQAVDDVKKGYIKAEEKSYQLQKLYEQRKMVMYLNMLRTCEGYNEIIFPHCACDSRRKGHVITAISITHFKLHACTEEGQLENQVIAFEWDEMQRWDTDEEGMAFCFEYARGEKKPRWVKIFTPYFNYMHECFERVFCELKWRKENIFQMARSQQRDVAT
Organism_Source Homo sapiens
Functional_Classification PDZ-domain-containing adaptor
Cellular_Localization Cytoplasm
Gene_Names SNX27
UniProt_ID Q96L92
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name PTHR PDZbm
Peptide_Sequence QEEWETVM
Peptide_Length 8
Peptide_SMILES CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](N)CCC(N)=O)[C@@H](C)O)C(C)C)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1051.14
Aliphatic_Index 36.25000
Aromaticity 0.12500
Average_Rotatable_Bonds 4.25000
Charge_at_pH_7 -2.99669
Isoelectric_Point 3.47280
Number_of_Hydrogen_Bond_Acceptors 15
Number_of_Hydrogen_Bond_Donors 15
Topological_Polar_Surface_Area 458.03000
X_logP_energy -2.83430
Interaction Information
Affinity KD=6 uM
Affinity_Assay Isothermal titration calorimetry
PDB_ID 4Z8J
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title A molecular code for endosomal recycling of phosphorylated cargos by the SNX27-retromer complex.
Release_Year 2016
PMID 27595347
DOI 10.1038/nsmb.3290