PPIRE07886

Target Protein Information
Protein_Name TNF receptor-associated factor 6
Protein_Sequence MSLLNCENSCGSSQSESDCCVAMASSCSAVTKDDSVGGTASTGNLSSSFMEEIQGYDVEFDPPLESKYECPICLMALREAVQTPCGHRFCKACIIKSIRDAGHKCPVDNEILLENQLFPDNFAKREILSLMVKCPNEGCLHKMELRHLEDHQAHCEFALMDCPQCQRPFQKFHINIHILKDCPRRQVSCDNCAASMAFEDKEIHDQNCPLANVICEYCNTILIREQMPNHYDLDCPTAPIPCTFSTFGCHEKMQRNHLARHLQENTQSHMRMLAQAVHSLSVIPDSGYISEVRNFQETIHQLEGRLVRQDHQIRELTAKMETQSMYVSELKRTIRTLEDKVAEIEAQQCNGIYIWKIGNFGMHLKCQEEEKPVVIHSPGFYTGKPGYKLCMRLHLQLPTAQRCANYISLFVHTMQGEYDSHLPWPFQGTIRLTILDQSEAPVRQNHEEIMDAKPELLAFQRPTIPRNPKGFGYVTFMHLEALRQRTFIKDDTLLVRCEVSTRFDMGSLRREGFQPRSTDAGV
Organism_Source Homo sapiens
Functional_Classification ubiquitin ligases
Cellular_Localization Cytoplasm
Gene_Names TRAF6
UniProt_ID Q9Y4K3
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name TRANCE-R peptide
Peptide_Sequence QMPTEDEY
Peptide_Length 8
Peptide_SMILES CSCC[C@H](NC(=O)[C@@H](N)CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Acetyl
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1012.06
Aliphatic_Index 0.00000
Aromaticity 0.12500
Average_Rotatable_Bonds 3.87500
Charge_at_pH_7 -2.99887
Isoelectric_Point 3.42471
Number_of_Hydrogen_Bond_Acceptors 16
Number_of_Hydrogen_Bond_Donors 14
Topological_Polar_Surface_Area 453.68000
X_logP_energy -4.14990
Interaction Information
Affinity KD=78 uM
Affinity_Assay Isothermal titration calorimetry
PDB_ID 1LB5
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Distinct molecular mechanism for initiating TRAF6 signalling.
Release_Year 2002
PMID 12140561
DOI 10.1038/nature00888