PPIRE07947

Target Protein Information
Protein_Name H-2 class I histocompatibility antigen, K-Q alpha chain
Protein_Sequence PRFISVGYVDDTELVRFDSDAENPRYEPRARWMEQVEPEYWERNTQIAKDNEQSSRVDLRTLLRYYNQSAGGSHTIQRMYGCDVGSDGRLLRGYEQVAYDGCDYIALNEDLKTWTAADMAALITKHKWEQAGAAERRRAYLEGACVEWLSRHLKNGNATLLRTDSPKAHVTHHSRPEDKVTLRCWALGFYPADITLTWQLNGEELTQDMELVETRPAGDGTFQKWASVVVPLGKEQYYTCHVYHQGLPKPLTLRWEPPPSAVSNTVIIAVLVVLGAAIVTGAVVAFVMMRRRNTGGKGGDYALAPGSQTSDLSLPDCKVMVHDPHSLA
Organism_Source Mus musculus
Functional_Classification MHC class I
Cellular_Localization Plasma membrane
Gene_Names H2-K1
UniProt_ID P14428
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name MUC1-8-5F8L
Peptide_Sequence SAPDFRPL
Peptide_Length 8
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@@H](N)CO)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 902.02
Aliphatic_Index 61.25000
Aromaticity 0.12500
Average_Rotatable_Bonds 3.00000
Charge_at_pH_7 -0.00157
Isoelectric_Point 6.33872
Number_of_Hydrogen_Bond_Acceptors 12
Number_of_Hydrogen_Bond_Donors 12
Topological_Polar_Surface_Area 368.87000
X_logP_energy -3.15673
Interaction Information
Affinity KD=300 nM
Affinity_Assay competitive radioligand binding assay
PDB_ID 2FO4
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Enhanced major histocompatibility complex class I binding and immune responses through anchor modification of the non-canonical tumour-associated mucin 1-8 peptide.
Release_Year 2006
PMID 17067310
DOI 10.1111/j.1365-2567.2006.02434.x