PPIRE07985
Target Protein Information
| Protein_Name | THO complex subunit 4 |
|---|---|
| Protein_Sequence | MADKMDMSLDDIIKLNRSQRGGRGGGRGRGRAGSQGGRGGAVQAAARVNRGGGPMRNRPAIARGAAGGGRNRPAPYSRPKQLPDKWQHDLFDSGFGGGAGVETGGKLLVSNLDFGVSDADIQELFAEFGTLKKAAVHYDRSGRSLGTADVHFERKADALKAMKQYNGVPLDGRPMNIQLVTSQIDTQRRPAQSINRGGMTRNRGSGGFGGGGTRRGTRGGSRGRGRGTGRNSKQQLSAEELDAQLDAYNARMDTS |
| Organism_Source | Mus musculus |
| Functional_Classification | nuclear export factors |
| Cellular_Localization | Nucleus |
| Gene_Names | Alyref |
| UniProt_ID | O08583 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | ICP27_103-110 |
|---|---|
| Peptide_Sequence | SVWSRLGA |
| Peptide_Length | 8 |
| Peptide_SMILES | CC(C)C[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](NC(=O)[C@@H](N)CO)C(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 875.00 |
|---|---|
| Aliphatic_Index | 97.50000 |
| Aromaticity | 0.12500 |
| Average_Rotatable_Bonds | 3.25000 |
| Charge_at_pH_7 | 0.99798 |
| Isoelectric_Point | 10.55000 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 12 |
| Number_of_Hydrogen_Bond_Donors | 15 |
| Topological_Polar_Surface_Area | 385.17000 |
| X_logP_energy | -3.88283 |
Interaction Information
| Affinity | KD=0.025 mM |
|---|---|
| Affinity_Assay | NMR chemical shift titration |
| PDB_ID | 2KT5 |
| Type | Inhibitor |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Structural basis for the recognition of cellular mRNA export factor REF by herpes viral proteins HSV-1 ICP27 and HVS ORF57. |
| Release_Year | 2011 |
| PMID | 21253573 |
| DOI | 10.1371/journal.ppat.1001244 |