PPIRE08024

Target Protein Information
Protein_Name H-2 class I histocompatibility antigen, K-Q alpha chain
Protein_Sequence PRFISVGYVDDTELVRFDSDAENPRYEPRARWMEQVEPEYWERNTQIAKDNEQSSRVDLRTLLRYYNQSAGGSHTIQRMYGCDVGSDGRLLRGYEQVAYDGCDYIALNEDLKTWTAADMAALITKHKWEQAGAAERRRAYLEGACVEWLSRHLKNGNATLLRTDSPKAHVTHHSRPEDKVTLRCWALGFYPADITLTWQLNGEELTQDMELVETRPAGDGTFQKWASVVVPLGKEQYYTCHVYHQGLPKPLTLRWEPPPSAVSNTVIIAVLVVLGAAIVTGAVVAFVMMRRRNTGGKGGDYALAPGSQTSDLSLPDCKVMVHDPHSLA
Organism_Source Mus musculus
Functional_Classification MHC class I
Cellular_Localization Plasma membrane
Gene_Names H2-K1
UniProt_ID P14428
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name pWM
Peptide_Sequence WIYVYRPM
Peptide_Length 8
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCSC)C(=O)O)C(C)C
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1127.37
Aliphatic_Index 85.00000
Aromaticity 0.37500
Average_Rotatable_Bonds 3.75000
Charge_at_pH_7 0.99628
Isoelectric_Point 9.17163
Number_of_Hydrogen_Bond_Acceptors 13
Number_of_Hydrogen_Bond_Donors 14
Topological_Polar_Surface_Area 376.38000
X_logP_energy 1.63717
Interaction Information
Affinity KD=15 mM
Affinity_Assay Surface plasmon resonance
PDB_ID 3RGV
Type Agonist
Structure
Reference Information
Document_Type Research Articles
Title A single T cell receptor bound to major histocompatibility complex class I and class II glycoproteins reveals switchable TCR conformers.
Release_Year 2011
PMID 21683626
DOI 10.1016/j.immuni.2011.04.017