PPIRE08097

Target Protein Information
Protein_Name Fizzy-related protein homolog
Protein_Sequence MDQDYERRLLRQIVIQNENTMPRVTEMRRTLTPASSPVSSPSKHGDRFIPSRAGANWSVNFHRINENEKSPSQNRKAKDATSDNGKDGLAYSALLKNELLGAGIEKVQDPQTEDRRLQPSTPEKKGLFTYSLSTKRSSPDDGNDVSPYSLSPVSNKSQKLLRSPRKPTRKISKIPFKVLDAPELQDDFYLNLVDWSSLNVLSVGLGTCVYLWSACTSQVTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAEQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNVFSKTRSTKVKWESVSVLNLFTRIR
Organism_Source Homo sapiens
Functional_Classification cadherins
Cellular_Localization Plasma membrane
Gene_Names FZR1
UniProt_ID Q9UM11
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name ADTC5
Peptide_Sequence CADTPPVC
Peptide_Length 8
Peptide_SMILES CC(C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CS)[C@@H](C)O)C(=O)N[C@@H](CS)C(=O)O
Chemical_Modification None
Cyclization_Method Side chain-side chain cyclization; C1<->C8; disulfide bond
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 804.93
Aliphatic_Index 48.75000
Aromaticity 0.00000
Average_Rotatable_Bonds 2.37500
Charge_at_pH_7 -1.12552
Isoelectric_Point 3.74996
Number_of_Hydrogen_Bond_Acceptors 13
Number_of_Hydrogen_Bond_Donors 11
Topological_Polar_Surface_Area 306.97000
X_logP_energy -3.80470
Interaction Information
Affinity IC50=0.3 mM
Affinity_Assay transepithelial electrical resistance assay
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Modulation of intercellular junctions by cyclic-ADT peptides as a method to reversibly increase blood-brain barrier permeability.
Release_Year 2015
PMID 25640479
DOI 10.1002/jps.24309