PPIRE08098
Target Protein Information
| Protein_Name | Envelope glycoprotein |
|---|---|
| Protein_Sequence | MGVTGILQLPRDRFKRTSFFLWVIILFQRTFSIPLGVIHNSTLQVNDVDKLVCRDKLSSTNQLRSVGLNLEGNGVATDVPSATKRWGFRSGVPPKVVNYEAGEWAENCYNLEIKKPDGSECLPAAPDGIRGFPRCRYVHKVSGTGPCAGDFAFHKEGAFFLYDRLASTVIYRGTTFAEGVVAFLILPQAKKDFFSSHPLREPVNATEDPSSGYYSTTIRYQATGFGTNETEYLFEVDNLTYVQLESRFTPQFLLQLNETIYTSGKRSNTTGKLIWKVNPEIDTTIGEWAFWETKKNLTRKIRSEELSFTVVSNGAKNISGQSPARTSSDPGTNTTTEDHKIMASENSSAMVQVHSQGREAAVSHLTTLATISTSPQSLTTKPGPDNSTHNTPVYKLDISEATQVEQHHRRTDNDSTASDTPSATTAAGPPKAENTNTSKSTDFLDPATTTSPQNHSETAGNNNTHHQDTGEESASSGKLGLITNTIAGVAGLITGGRRTRREAIVNAQPKCNPNLHYWTTQDEGAAIGLAWIPYFGPAAEGIYTEGLMHNQNGLICGLRQLANETTQALQLFLRATTELRTFSILNRKAIDFLLQRWGGTCHILGPDCCIEPHDWTKNITDKIDQIIHDFVDKTLPDQGDNDNWWTGWRQWIPAGIGVTGVIIAVIALFCICKFVF |
| Organism_Source | Zaire ebolavirus (strain Eckron-76) |
| Functional_Classification | viral envelope glycoprotein |
| Cellular_Localization | Extracellular |
| Gene_Names | GP |
| UniProt_ID | P87671 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | Pep-3.3 |
|---|---|
| Peptide_Sequence | CDYFFWYC |
| Peptide_Length | 8 |
| Peptide_SMILES | N[C@@H](CS)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CS)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | Side chain-side chain cyclization; C1<->C8; disulfide bond |
| Linear/Cyclic | Cyclic |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1146.30 |
|---|---|
| Aliphatic_Index | 0.00000 |
| Aromaticity | 0.62500 |
| Average_Rotatable_Bonds | 3.62500 |
| Charge_at_pH_7 | -1.12722 |
| Isoelectric_Point | 3.74995 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 14 |
| Number_of_Hydrogen_Bond_Donors | 15 |
| Topological_Polar_Surface_Area | 360.57000 |
| X_logP_energy | 1.23220 |
Interaction Information
| Affinity | KD=69.7 uM |
|---|---|
| Affinity_Assay | Bio-Layer Interferometry |
| PDB_ID | 5F1B |
| Type | Inhibitor |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Novel cyclo-peptides inhibit Ebola pseudotyped virus entry by targeting primed GP protein. |
| Release_Year | 2018 |
| PMID | 29709562 |
| DOI | 10.1016/j.antiviral.2018.04.020 |