PPIRE08100

Target Protein Information
Protein_Name Cyclin-A2
Protein_Sequence MLGNSAPGPATREAGSALLALQQTALQEDQENINPEKAAPVQQPRTRAALAVLKSGNPRGLAQQQRPKTRRVAPLKDLPVNDEHVTVPPWKANSKQPAFTIHVDEAEKEAQKKPAESQKIEREDALAFNSAISLPGPRKPLVPLDYPMDGSFESPHTMDMSIILEDEKPVSVNEVPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKYHGVSLLNPPETLNL
Organism_Source Homo sapiens
Functional_Classification extracellular matrix proteins
Cellular_Localization Extracellular
Gene_Names CCNA2
UniProt_ID P20248
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name CCN1 epitope cyclic peptide
Peptide_Sequence CGLECNFG
Peptide_Length 8
Peptide_SMILES CC(C)C[C@H](NC(=O)CNC(=O)[C@@H](N)CS)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)O
Chemical_Modification None
Cyclization_Method side chain-side chain cyclization; C1<->C5; disulfide bond
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 841.95
Aliphatic_Index 48.75000
Aromaticity 0.12500
Average_Rotatable_Bonds 3.25000
Charge_at_pH_7 -1.12419
Isoelectric_Point 3.84994
Number_of_Hydrogen_Bond_Acceptors 13
Number_of_Hydrogen_Bond_Donors 13
Topological_Polar_Surface_Area 347.41000
X_logP_energy -4.05670
Interaction Information
Affinity KD=250 nM
Affinity_Assay Surface plasmon resonance
PDB_ID 5WTT
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Molecular basis for the recognition of CCN1 by monoclonal antibody 093G9.
Release_Year 2017
PMID 28608634
DOI 10.1002/jmr.2645