PPIRE08106

Target Protein Information
Protein_Name C-C chemokine receptor type 3
Protein_Sequence MTTSLDTVETFGTTSYYDDVGLLCEKADTRALMAQFVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVYSWRHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFGNDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYLRHFFHRHLLMHLGRYIPFLPSEKLERTSSVSPSTAEPELSIVF
Organism_Source Homo sapiens
Functional_Classification G protein-coupled receptor
Cellular_Localization Plasma membrane
Gene_Names CCR3
UniProt_ID P51677
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name CPWYFWPC
Peptide_Sequence CPWYFWPC
Peptide_Length 8
Peptide_SMILES N[C@@H](CS)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CS)C(=O)O
Chemical_Modification None
Cyclization_Method side chain-side chain cyclization; C1<->C8; disulfide bond
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1101.31
Aliphatic_Index 0.00000
Aromaticity 0.50000
Average_Rotatable_Bonds 2.87500
Charge_at_pH_7 -0.12682
Isoelectric_Point 5.82405
Number_of_Hydrogen_Bond_Acceptors 12
Number_of_Hydrogen_Bond_Donors 12
Topological_Polar_Surface_Area 301.25000
X_logP_energy 2.30290
Interaction Information
Affinity IC50=20 uM
Affinity_Assay competitive radioligand binding assay
PDB_ID None
Type antagonist
Structure
Reference Information
Document_Type Research Articles
Title Functional inhibition of CCR3-dependent responses by peptides derived from phage libraries.
Release_Year 2001
PMID 11745373
DOI 10.1002/1521-4141(200112)31:12<3535::aid-immu3535>3.0.co;2-3