PPIRE08130

Target Protein Information
Protein_Name Somatostatin receptor type 2
Protein_Sequence MELTSEQFNGSQVWIPSPFDLNGSLGPSNGSNQTEPYYDMTSNAVLTFIYFVVCVVGLCGNTLVIYVILRYAKMKTITNIYILNLAIADELFMLGLPFLAMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMINVAVWGVSLLVILPIMIYAGLRSNQWGRSSCTINWPGESGAWYTGFIIYAFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFNVSSVSVAISPTPALKGMFDFVVILTYANSCANPILYAFLSDNFKKSFQNVLCLVKVSGAEDGERSDSKQDKSRLNETTETQRTLLNGDLQTSI
Organism_Source Rattus norvegicus
Functional_Classification G protein-coupled receptor
Cellular_Localization Plasma membrane
Gene_Names Sstr2
UniProt_ID P30680
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name HYNIC-TOC
Peptide_Sequence fCYwKTCX
Peptide_Length 8
Peptide_SMILES C[C@@H](O)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CS)NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@@H](CS)C(=O)NCC(=O)O
Chemical_Modification X8=Thr(ol)
Cyclization_Method Side chain-side chain cyclization; C2<->C7; disulfide bond
Linear/Cyclic Cyclic
N-terminal_Modification Hynic
C-terminal_Modification threoninol
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1007.19
Aliphatic_Index 0.00000
Aromaticity 0.37500
Average_Rotatable_Bonds 3.50000
Charge_at_pH_7 0.87289
Isoelectric_Point 8.22117
Number_of_Hydrogen_Bond_Acceptors 14
Number_of_Hydrogen_Bond_Donors 15
Topological_Polar_Surface_Area 349.29000
X_logP_energy -1.29230
Interaction Information
Affinity IC50=3.74 nM
Affinity_Assay competitive radioligand binding assay
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Research Articles
Title (99m)Tc-labeled dimeric octreotide peptide: a radiotracer with high tumor uptake for single-photon emission computed tomography imaging of somatostatin receptor subtype 2-positive tumors.
Release_Year 2013
PMID 23768172
DOI 10.1021/mp400040z