PPIRE08182

Target Protein Information
Protein_Name Tumor susceptibility gene 101 protein
Protein_Sequence MAVSESQLKKMVSKYKYRDLTVRETVNVITLYKDLKPVLDSYVFNDGSSRELMNLTGTIPVPYRGNTYNIPICLWLLDTYPYNPPICFVKPTSSMTIKTGKHVDANGKIYLPYLHEWKHPQSDLLGLIQVMIVVFGDEPPVFSRPISASYPPYQATGPPNTSYMPGMPGGISPYPSGYPPNPSGYPGCPYPPGGPYPATTSSQYPSQPPVTTVGPSRDGTISEDTIRASLISAVSDKLRWRMKEEMDRAQAELNALKRTEEDLKKGHQKLEEMVTRLDQEVAEVDKNIELLKKKDEELSSALEKMENQSENNDIDEVIIPTAPLYKQILNLYAEENAIEDTIFYLGEALRRGVIDLDVFLKHVRLLSRKQFQLRALMQKARKTAGLSDLY
Organism_Source Homo sapiens
Functional_Classification ubiquitin-binding proteins
Cellular_Localization Cytoplasm
Gene_Names TSG101
UniProt_ID Q99816
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name A3
Peptide_Sequence SGAIYWNV
Peptide_Length 8
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)CNC(=O)[C@@H](N)CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)O)C(C)C
Chemical_Modification None
Cyclization_Method Main chain-main chain cyclization; S1<->V8; amide bond
Linear/Cyclic Cyclic
N-terminal_Modification None
C-terminal_Modification None
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 909.01
Aliphatic_Index 97.50000
Aromaticity 0.25000
Average_Rotatable_Bonds 3.12500
Charge_at_pH_7 -0.00287
Isoelectric_Point 6.09320
Number_of_Hydrogen_Bond_Acceptors 12
Number_of_Hydrogen_Bond_Donors 13
Topological_Polar_Surface_Area 366.36000
X_logP_energy -2.31470
Interaction Information
Affinity IC50=33.7 uM
Affinity_Assay ELISA
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Development of a Cyclic Peptide Inhibitor of the p6/UEV Protein-Protein Interaction.
Release_Year 2019
PMID 31411851
DOI 10.1021/acschembio.9b00627