PPIRE08196

Target Protein Information
Protein_Name Tumor susceptibility gene 101 protein
Protein_Sequence MAVSESQLKKMVSKYKYRDLTVRETVNVITLYKDLKPVLDSYVFNDGSSRELMNLTGTIPVPYRGNTYNIPICLWLLDTYPYNPPICFVKPTSSMTIKTGKHVDANGKIYLPYLHEWKHPQSDLLGLIQVMIVVFGDEPPVFSRPISASYPPYQATGPPNTSYMPGMPGGISPYPSGYPPNPSGYPGCPYPPGGPYPATTSSQYPSQPPVTTVGPSRDGTISEDTIRASLISAVSDKLRWRMKEEMDRAQAELNALKRTEEDLKKGHQKLEEMVTRLDQEVAEVDKNIELLKKKDEELSSALEKMENQSENNDIDEVIIPTAPLYKQILNLYAEENAIEDTIFYLGEALRRGVIDLDVFLKHVRLLSRKQFQLRALMQKARKTAGLSDLY
Organism_Source Homo sapiens
Functional_Classification ubiquitin-binding proteins
Cellular_Localization Lysosome
Gene_Names TSG101
UniProt_ID Q99816
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name cyclic peptide 11
Peptide_Sequence WIYWNVSG
Peptide_Length 8
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)NCC(=O)O)C(C)C
Chemical_Modification None
Cyclization_Method Main chain-main chain cyclization; W1<->G8; amide bond
Linear/Cyclic Cyclic
N-terminal_Modification None
C-terminal_Modification None
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1024.14
Aliphatic_Index 85.00000
Aromaticity 0.37500
Average_Rotatable_Bonds 3.37500
Charge_at_pH_7 -0.00287
Isoelectric_Point 6.09320
Number_of_Hydrogen_Bond_Acceptors 12
Number_of_Hydrogen_Bond_Donors 14
Topological_Polar_Surface_Area 382.15000
X_logP_energy -0.61060
Interaction Information
Affinity IC50=7 uM
Affinity_Assay Enzyme Inhibition Kinetics
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Inhibition of HIV budding by a genetically selected cyclic peptide targeting the Gag-TSG101 interaction.
Release_Year 2008
PMID 19053244
DOI 10.1021/cb800193n