PPIRE08199

Target Protein Information
Protein_Name Somatostatin receptor type 2
Protein_Sequence MDMADEPLNGSHTWLSIPFDLNGSVVSTNTSNQTEPYYDLTSNAVLTFIYFVVCIIGLCGNTLVIYVILRYAKMKTITNIYILNLAIADELFMLGLPFLAMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSNQWGRSSCTINWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFNVSSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSFQNVLCLVKVSGTDDGERSDSKQDKSRLNETTETQRTLLNGDLQTSI
Organism_Source Homo sapiens
Functional_Classification G protein-coupled receptor
Cellular_Localization Plasma membrane
Gene_Names SSTR2
UniProt_ID P30874
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name BIM-23014C
Peptide_Sequence XCYwKVCT
Peptide_Length 8
Peptide_SMILES CC(C)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CS)NC(=O)CN)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)O)[C@@H](C)O
Chemical_Modification X1=3-(2-naphthyl)-D-alanine
Cyclization_Method Side chain-side chain cyclization; C2<->C7; disulfide bond
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 959.15
Aliphatic_Index 36.25000
Aromaticity 0.25000
Average_Rotatable_Bonds 3.37500
Charge_at_pH_7 0.87289
Isoelectric_Point 8.22117
Number_of_Hydrogen_Bond_Acceptors 14
Number_of_Hydrogen_Bond_Donors 15
Topological_Polar_Surface_Area 349.29000
X_logP_energy -1.87900
Interaction Information
Affinity IC50=0.73 nM
Affinity_Assay radioligand binding assay
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Research Articles
Title Octapeptide analogues of somatostatin inhibit the clonal growth and vasoactive intestinal peptide-stimulated cyclic AMP formation in human small cell lung cancer cells.
Release_Year 1991
PMID 1686316
DOI 10.1016/0196-9781(91)90143-d