PPIRE08204

Target Protein Information
Protein_Name Splicing factor 45
Protein_Sequence MSLYDDLGVETSDSKTEGWSKNFKLLQSQLQVKKAALTQAKSQRTKQSTVLAPVIDLKRGGSSDDRQIVDTPPHVAAGLKDPVPSGFSAGEVLIPLADEYDPMFPNDYEKVVKRQREERQRQRELERQKEIEEREKRRKDRHEASGFARRPDPDSDEDEDYERERRKRSMGGAAIAPPTSLVEKDKELPRDFPYEEDSRPRSQSSKAAIPPPVYEEQDRPRSPTGPSNSFLANMGGTVAHKIMQKYGFREGQGLGKHEQGLSTALSVEKTSKRGGKIIVGDATEKDASKKSDSNPLTEILKCPTKVVLLRNMVGAGEVDEDLEVETKEECEKYGKVGKCVIFEIPGAPDDEAVRIFLEFERVESAIKAVVDLNGRYFGGRVVKACFYNLDKFRVLDLAEQV
Organism_Source Homo sapiens
Functional_Classification RNA-binding proteins
Cellular_Localization Nucleus
Gene_Names RBM17
UniProt_ID Q96I25
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name peptide 8
Peptide_Sequence XKSRWDEK
Peptide_Length 8
Peptide_SMILES N=C(N)NCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)CN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)O
Chemical_Modification X1=Nepsilon-methyllysine
Cyclization_Method Side chain-side chain cyclization; X1<->E7; other bonds
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1005.10
Aliphatic_Index 0.00000
Aromaticity 0.12500
Average_Rotatable_Bonds 4.37500
Charge_at_pH_7 0.99961
Isoelectric_Point 9.53485
Number_of_Hydrogen_Bond_Acceptors 15
Number_of_Hydrogen_Bond_Donors 18
Topological_Polar_Surface_Area 491.58000
X_logP_energy -4.99963
Interaction Information
Affinity KD=1.26 uM
Affinity_Assay Isothermal titration calorimetry
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Rational Design of Cyclic Peptide Inhibitors of U2AF Homology Motif (UHM)Domains To Modulate Pre-mRNA Splicing.
Release_Year 2016
PMID 27753493
DOI 10.1021/acs.jmedchem.6b01118