PPIRE08208

Target Protein Information
Protein_Name Transcription factor Jun
Protein_Sequence MTAKMETTFYDDALNASFLPSESGPYGYSNPKILKQSMTLNLADPVGSLKPHLRAKNSDLLTSPDVGLLKLASPELERLIIQSSNGHITTTPTPTQFLCPKNVTDEQEGFAEGFVRALAELHSQNTLPSVTSAAQPVNGAGMVAPAVASVAGGSGSGGFSASLHSEPPVYANLSNFNPGALSSGGGAPSYGAAGLAFPAQPQQQQQPPHHLPQQMPVQHPRLQALKEEPQTVPEMPGETPPLSPIDMESQERIKAERKRMRNRIAASKCRKRKLERIARLEEKVKTLKAQNSELASTANMLREQVAQLKQKVMNHVNSGCQLMLTQQLQTF
Organism_Source Homo sapiens
Functional_Classification AP-1 family
Cellular_Localization Nucleus
Gene_Names JUN
UniProt_ID P05412
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Grassypeptolide G
Peptide_Sequence XVPXXPVX
Peptide_Length 8
Peptide_SMILES CC(C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)CN)C(C)C)C(=O)NCC(=O)O
Chemical_Modification X1=2-methyl-3-aminobutyric acid; X4=thiazoline carboxylic acid (Ala-thn-ca); X5=thiazoline carboxylic acid (N-Me-Phe-thn-ca); X8=phenyllactic acid
Cyclization_Method Main chain-main chain cyclization; X8<->X1; other bonds
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 638.72
Aliphatic_Index 72.50000
Aromaticity 0.00000
Average_Rotatable_Bonds 1.87500
Charge_at_pH_7 -0.00202
Isoelectric_Point 6.10000
Number_of_Hydrogen_Bond_Acceptors 9
Number_of_Hydrogen_Bond_Donors 7
Topological_Polar_Surface_Area 249.44000
X_logP_energy -3.35810
Interaction Information
Affinity IC50=6 uM
Affinity_Assay TR-FRET assay
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Grassypeptolides F and G, cyanobacterial peptides from Lyngbya majuscula.
Release_Year 2011
PMID 21806011
DOI 10.1021/np2005083