PPIRE08213
Target Protein Information
| Protein_Name | cAMP-dependent protein kinase type II-alpha regulatory subunit |
|---|---|
| Protein_Sequence | MSHIQIPPGLTELLQGYTVEVLRQQPPDLVEFAVEYFTRLREARAPASVLPAATPRQSLGHPPPEPGPDRVADAKGDSESEEDEDLEVPVPSRFNRRVSVCAETYNPDEEEEDTDPRVIHPKTDEQRCRLQEACKDILLFKNLDQEQLSQVLDAMFERIVKADEHVIDQGDDGDNFYVIERGTYDILVTKDNQTRSVGQYDNRGSFGELALMYNTPRAATIVATSEGSLWGLDRVTFRRIIVKNNAKKRKMFESFIESVPLLKSLEVSERMKIVDVIGEKIYKDGERIITQGEKADSFYIIESGEVSILIRSRTKSNKDGGNQEVEIARCHKGQYFGELALVTNKPRAASAYAVGDVKCLVMDVQAFERLLGPCMDIMKRNISHYEEQLVKMFGSSVDLGNLGQ |
| Organism_Source | Homo sapiens |
| Functional_Classification | kinases |
| Cellular_Localization | Cytoplasm |
| Gene_Names | PRKAR2A |
| UniProt_ID | P13861 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | STAD-2 |
|---|---|
| Peptide_Sequence | XXKKLXTT |
| Peptide_Length | 8 |
| Peptide_SMILES | CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)CN)C(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)O)[C@@H](C)O)[C@@H](C)O |
| Chemical_Modification | X1=beta-alanine; X2=S-pentenylalanine; X6=S-pentenylalanine |
| Cyclization_Method | Side chain-side chain cyclization; X2<->X6; other bonds |
| Linear/Cyclic | Cyclic |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 760.89 |
|---|---|
| Aliphatic_Index | 48.75000 |
| Aromaticity | 0.00000 |
| Average_Rotatable_Bonds | 3.37500 |
| Charge_at_pH_7 | 1.99739 |
| Isoelectric_Point | 10.80538 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 13 |
| Number_of_Hydrogen_Bond_Donors | 13 |
| Topological_Polar_Surface_Area | 359.52000 |
| X_logP_energy | -5.24820 |
Interaction Information
| Affinity | IC50=1 uM |
|---|---|
| Affinity_Assay | parasite growth inhibition assay by flow cytometry |
| PDB_ID | None |
| Type | Inhibitor |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | The Stapled AKAP Disruptor Peptide STAD-2 Displays Antimalarial Activity through a PKA-Independent Mechanism. |
| Release_Year | 2015 |
| PMID | 26010880 |
| DOI | 10.1371/journal.pone.0129239 |