PPIRE08232

Target Protein Information
Protein_Name Interleukin-5
Protein_Sequence MRRMLLHLSVLTLSCVWATAMEIPMSTVVKETLTQLSAHRALLTSNETMRLPVPTHKNHQLCIGEIFQGLDILKNQTVRGGTVEMLFQNLSLIKKYIDRQKEKCGEERRRTRQFLDYLQEFLGVMSTEWAMEG
Organism_Source Mus musculus
Functional_Classification interleukins
Cellular_Localization Extracellular
Gene_Names Il5
UniProt_ID P04401
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Thalassospiramide A
Peptide_Sequence XXVXVXVS
Peptide_Length 8
Peptide_SMILES CC(C)[C@H](NC(=O)CNC(=O)CN)C(=O)NCC(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)O)C(C)C)C(C)C
Chemical_Modification X1=dec-3-enoic acid; X2=N-methyltyrosine; X3=4-amino-5-hydroxy-penta-2-enoic acid; X4=4-amino-3,5-dihydroxy-pentanoic acid
Cyclization_Method main chain-main chain cyclization; S8<->X1; amide bond
Linear/Cyclic Cyclic
N-terminal_Modification None
C-terminal_Modification None
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 630.70
Aliphatic_Index 108.75000
Aromaticity 0.00000
Average_Rotatable_Bonds 2.37500
Charge_at_pH_7 -0.00202
Isoelectric_Point 6.10000
Number_of_Hydrogen_Bond_Acceptors 10
Number_of_Hydrogen_Bond_Donors 10
Topological_Polar_Surface_Area 287.25000
X_logP_energy -4.72220
Interaction Information
Affinity IC50=10 uM
Affinity_Assay interleukin-5 production inhibition assay
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Thalassospiramides A and B, immunosuppressive peptides from the marine bacterium Thalassospira sp.
Release_Year 2007
PMID 17373804
DOI 10.1021/ol070294u