PPIRE08234

Target Protein Information
Protein_Name Mu-type opioid receptor
Protein_Sequence MDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCGLNRTGLGGNDSLCPQTGSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQQNSTRVRQNTREHPSTANTVDRTNHQLENLEAETAPLP
Organism_Source Rattus norvegicus
Functional_Classification G protein-coupled receptor
Cellular_Localization Plasma membrane
Gene_Names Oprm1
UniProt_ID P33535
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name D-Tic-Cys-Tyr-D-Trp-Lys-Thr-Pen-Thr-NH2
Peptide_Sequence XCYwKXTT
Peptide_Length 8
Peptide_SMILES C[C@@H](O)[C@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CS)NC(=O)CN)[C@@H](C)O)C(=O)O
Chemical_Modification X1=1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid; X7=penicillamine
Cyclization_Method Side chain-side chain cyclization; C2<->X7; disulfide bond
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 915.03
Aliphatic_Index 0.00000
Aromaticity 0.25000
Average_Rotatable_Bonds 3.25000
Charge_at_pH_7 0.93486
Isoelectric_Point 8.52294
Number_of_Hydrogen_Bond_Acceptors 14
Number_of_Hydrogen_Bond_Donors 15
Topological_Polar_Surface_Area 369.52000
X_logP_energy -3.45260
Interaction Information
Affinity IC50=1.2 nM
Affinity_Assay radioligand competition binding assay
PDB_ID None
Type antagonist
Structure
Reference Information
Document_Type Research Articles
Title Identification and characterisation of peptides from a boarfish (Capros aper)protein hydrolysate displaying in vitro dipeptidyl peptidase-IV (DPP-IV)inhibitory and insulinotropic activity.
Release_Year 1991
PMID None
DOI 10.1021/ja00006a055