PPIRE08248
Target Protein Information
| Protein_Name | Protein numb |
|---|---|
| Protein_Sequence | MGNSSSHTHEPLERGFTRGKFGDVKNGKSASFRFSKKSPKKMDRLRRSFRDSFRRRKDRVPESSKPHQWQADEEAVRSATCSFSVKYLGCVEVFESRGMQVCEEALKVLRQSRRRPVRGLLHVSGDGLRVVDDETKGLIVDQTIEKVSFCAPDRNHERGFSYICRDGTTRRWMCHGFLACKDSGERLSHAVGCAFAVCLERKQRRDKECGVTMTFDTKNSTFTRTGSFRQQTLTERLAMATVGTNERSVDGPGSAMPGPPAATVKPFNPFAIERPHATPNMLERQSSFRLSTIGSQSPFKRQMSLRINDLPSNADRQRAFLTAAAGNPMQTPLRSVSPIAEVSPAKSAGADPLSAAAVAADSVSQLCQELSQGLSLLTQTDALLAAGEDLNFNNNRSINQNIIAAEKQVQHVHSYAPPTAQVTPRVASTTPTYQTLHSQSPSRSEQSIETSTELPNAEQWLGHVVRSTSPAAPKRPTYLANVGRAQTLASGTGAAVGGGGPDDPFDAEWVANVAAAKQLSPDLPIPSTARSPLARHSTNPFISPPKAPAQSFQVQL |
| Organism_Source | Drosophila melanogaster |
| Functional_Classification | PTB domains |
| Cellular_Localization | Cytoplasm |
| Gene_Names | numb |
| UniProt_ID | P16554 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | GPpY |
|---|---|
| Peptide_Sequence | AYIGPpYL |
| Peptide_Length | 8 |
| Peptide_SMILES | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)N)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)O |
| Chemical_Modification | 5=phosphotyrosine |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Acetyl |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 893.05 |
|---|---|
| Aliphatic_Index | 110.00000 |
| Aromaticity | 0.25000 |
| Average_Rotatable_Bonds | 2.62500 |
| Charge_at_pH_7 | -0.00372 |
| Isoelectric_Point | 6.08660 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 11 |
| Number_of_Hydrogen_Bond_Donors | 9 |
| Topological_Polar_Surface_Area | 289.90000 |
| X_logP_energy | 0.44440 |
Interaction Information
| Affinity | KD=0.53 mM |
|---|---|
| Affinity_Assay | Fluorescence Polarization |
| PDB_ID | 2NMB |
| Type | Affinity ligand |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Structure of a Numb PTB domain-peptide complex suggests a basis for diverse binding specificity |
| Release_Year | 1998 |
| PMID | 9846878 |
| DOI | 10.1038/4185 |