PPIRE08288
Target Protein Information
| Protein_Name | Baculoviral IAP repeat-containing protein 5 |
|---|---|
| Protein_Sequence | MGAPTLPPAWQPFLKDHRISTFKNWPFLEGCACTPERMAEAGFIHCPTENEPDLAQCFFCFKELEGWEPDDDPIEEHKKHSSGCAFLSVKKQFEELTLGEFLKLDRERAKNKIAKETNNKKKEFEETAKKVRRAIEQLAAMD |
| Organism_Source | Homo sapiens |
| Functional_Classification | inhibitor of apoptosis proteins |
| Cellular_Localization | Nucleus |
| Gene_Names | BIRC5 |
| UniProt_ID | O15392 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | hSgo1 N-terminal peptide |
|---|---|
| Peptide_Sequence | AKERCGSGK |
| Peptide_Length | 9 |
| Peptide_SMILES | C[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CS)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | amide |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 935.07 |
|---|---|
| Aliphatic_Index | 11.11111 |
| Aromaticity | 0.00000 |
| Average_Rotatable_Bonds | 3.77778 |
| Charge_at_pH_7 | 1.93719 |
| Isoelectric_Point | 9.67375 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 16 |
| Number_of_Hydrogen_Bond_Donors | 18 |
| Topological_Polar_Surface_Area | 467.59000 |
| X_logP_energy | -7.13243 |
Interaction Information
| Affinity | KD=6.2 uM |
|---|---|
| Affinity_Assay | fluorescence anisotropy |
| PDB_ID | 4A0I |
| Type | Affinity ligand |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Structural basis for the recognition of phosphorylated histone h3 by the survivin subunit of the chromosomal passenger complex. |
| Release_Year | 2011 |
| PMID | 22032967 |
| DOI | 10.1016/j.str.2011.09.002 |