PPIRE08306

Target Protein Information
Protein_Name Urokinase plasminogen activator surface receptor
Protein_Sequence MGHPPLLPLLLLLHTCVPASWGLRCMQCKTNGDCRVEECALGQDLCRTTIVRLWEEGEELELVEKSCTHSEKTNRTLSYRTGLKITSLTEVVCGLDLCNQGNSGRAVTYSRSRYLECISCGSSDMSCERGRHQSLQCRSPEEQCLDVVTHWIQEGEEGRPKDDRHLRGCGYLPGCPGSNGFHNNDTFHFLKCCNTTKCNEGPILELENLPQNGRQCYSCKGNSTHGCSSEETFLIDCRGPMNQCLVATGTHEPKNQSYMVRGCATASMCQHAHLGDAFSMNHIDVSCCTKSGCNHPDLDVQYRSGAAPQPGPAHLSLTITLLMTARLWGGTLLWT
Organism_Source Homo sapiens
Functional_Classification GPI-anchored receptors
Cellular_Localization Extracellular
Gene_Names PLAUR
UniProt_ID Q03405
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name AE108
Peptide_Sequence arfhrYLWS
Peptide_Length 9
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CO)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1235.41
Aliphatic_Index 54.44444
Aromaticity 0.33333
Average_Rotatable_Bonds 4.00000
Charge_at_pH_7 2.08804
Isoelectric_Point 11.14768
Number_of_Hydrogen_Bond_Acceptors 15
Number_of_Hydrogen_Bond_Donors 20
Topological_Polar_Surface_Area 504.85000
X_logP_energy -2.25766
Interaction Information
Affinity KD=0.63 nM
Affinity_Assay Surface plasmon resonance
PDB_ID None
Type antagonist
Structure
Reference Information
Document_Type Research Articles
Title Peptide-derived antagonists of the urokinase receptor. affinity maturation by combinatorial chemistry, identification of functional epitopes, and inhibitory effect on cancer cell intravasation.
Release_Year 2001
PMID 11580291
DOI 10.1021/bi010662g