PPIRE08357

Target Protein Information
Protein_Name Gastrin/cholecystokinin type B receptor
Protein_Sequence MELLKLNRSVQGTGPGPGASLCRPGAPLLNSSSVGNLSCEPPRIRGAGTRELELAIRITLYAVIFLMSVGGNMLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTFIFGTVICKAVSYLMGVSVSVSTLSLVAIALERYSAICRPLQARVWQTRSHAARVIVATWLLSGLLMVPYPVYTVVQPVGPRVLQCVHRWPSARVRQTWSVLLLLLLFFIPGVVMAVAYGLISRELYLGLRFDGDSDSDSQSRVRNQGGLPGAVHQNGRCRPETGAVGEDSDGCYVQLPRSRPALELTALTAPGPGSGSRPTQAKLLAKKRVVRMLLVIVVLFFLCWLPVYSANTWRAFDGPGAHRALSGAPISFIHLLSYASACVNPLVYCFMHRRFRQACLETCARCCPRPPRARPRALPDEDPPTPSIASLSRLSYTTISTLGPG
Organism_Source Homo sapiens
Functional_Classification G protein-coupled receptor
Cellular_Localization Plasma membrane
Gene_Names CCKBR
UniProt_ID P32239
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Sargastrin
Peptide_Sequence DFXGWHXDF
Peptide_Length 9
Peptide_SMILES N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
Chemical_Modification X3=homopropargylglycine; X7=homopropargylglycine
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Dota
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1037.06
Aliphatic_Index 0.00000
Aromaticity 0.33333
Average_Rotatable_Bonds 3.22222
Charge_at_pH_7 -1.91021
Isoelectric_Point 4.10657
Number_of_Hydrogen_Bond_Acceptors 13
Number_of_Hydrogen_Bond_Donors 14
Topological_Polar_Surface_Area 415.19000
X_logP_energy -2.70450
Interaction Information
Affinity IC50=0.6 nM
Affinity_Assay quantitative autoradiography
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Research Articles
Title Comparison of the binding and internalization properties of 12 DOTA-coupled and 111In-labelled CCK2/gastrin receptor binding peptides: a collaborative project under COST Action BM0607.
Release_Year 2011
PMID 21523391
DOI 10.1007/s00259-011-1816-y