PPIRE08371

Target Protein Information
Protein_Name Urokinase plasminogen activator surface receptor
Protein_Sequence MGHPPLLPLLLLLHTCVPASWGLRCMQCKTNGDCRVEECALGQDLCRTTIVRLWEEGEELELVEKSCTHSEKTNRTLSYRTGLKITSLTEVVCGLDLCNQGNSGRAVTYSRSRYLECISCGSSDMSCERGRHQSLQCRSPEEQCLDVVTHWIQEGEEGRPKDDRHLRGCGYLPGCPGSNGFHNNDTFHFLKCCNTTKCNEGPILELENLPQNGRQCYSCKGNSTHGCSSEETFLIDCRGPMNQCLVATGTHEPKNQSYMVRGCATASMCQHAHLGDAFSMNHIDVSCCTKSGCNHPDLDVQYRSGAAPQPGPAHLSLTITLLMTARLWGGTLLWT
Organism_Source Homo sapiens
Functional_Classification GPI-anchored receptors
Cellular_Localization Plasma membrane
Gene_Names PLAUR
UniProt_ID Q03405
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name CB-TE2A-PA-AE105
Peptide_Sequence DXFsrYLWS
Peptide_Length 9
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CO)C(=O)O
Chemical_Modification X2=cyclohexylalanine
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Cb-Te2A-Pa
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1130.22
Aliphatic_Index 43.33333
Aromaticity 0.33333
Average_Rotatable_Bonds 3.66667
Charge_at_pH_7 -0.00242
Isoelectric_Point 6.33190
Number_of_Hydrogen_Bond_Acceptors 15
Number_of_Hydrogen_Bond_Donors 18
Topological_Polar_Surface_Area 471.80000
X_logP_energy -3.40823
Interaction Information
Affinity KD=27 nM
Affinity_Assay Surface plasmon resonance
PDB_ID None
Type antagonist
Structure
Reference Information
Document_Type Research Articles
Title Improved PET imaging of uPAR expression using new (64)Cu-labeled cross-bridged peptide ligands: comparative in vitro and in vivo studies.
Release_Year 2013
PMID 24052804
DOI 10.7150/thno.6810