PPIRE08400

Target Protein Information
Protein_Name Harmonin
Protein_Sequence MDRKVAREFRHKVDFLIENDAEKDYLYDVLRMYHQTMDVAVLVGDLKLVINEPSRLPLFDAIRPLIPLKHQVEYDQLTPRRSRKLKEVRLDRLHPEGLGLSVRGGLEFGCGLFISHLIKGGQADSVGLQVGDEIVRINGYSISSCTHEEVINLIRTKKTVSIKVRHIGLIPVKSSPDEPLTWQYVDQFVSESGGVRGSLGSPGNRENKEKKVFISLVGSRGLGCSISSGPIQKPGIFISHVKPGSLSAEVGLEIGDQIVEVNGVDFSNLDHKEAVNVLKSSRSLTISIVAAAGRELFMTDRERLAEARQRELQRQELLMQKRLAMESNKILQEQQEMERQRRKEIAQKAAEENERYRKEMEQIVEEEEKFKKQWEEDWGSKEQLLLPKTITAEVHPVPLRKPKYDQGVEPELEPADDLDGGTEEQGEQDFRKYEEGFDPYSMFTPEQIMGKDVRLLRIKKEGSLDLALEGGVDSPIGKVVVSAVYERGAAERHGGIVKGDEIMAINGKIVTDYTLAEAEAALQKAWNQGGDWIDLVVAVCPPKEYDDELTFF
Organism_Source Homo sapiens
Functional_Classification scaffold protein
Cellular_Localization Cytoplasm
Gene_Names USH1C
UniProt_ID Q9Y6N9
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Cad23-PBM peptide
Peptide_Sequence ETPLEITEL
Peptide_Length 9
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H](N)CCC(=O)O)[C@@H](C)O)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1044.17
Aliphatic_Index 130.00000
Aromaticity 0.00000
Average_Rotatable_Bonds 3.66667
Charge_at_pH_7 -2.99669
Isoelectric_Point 3.47280
Number_of_Hydrogen_Bond_Acceptors 15
Number_of_Hydrogen_Bond_Donors 14
Topological_Polar_Surface_Area 439.69000
X_logP_energy -2.72280
Interaction Information
Affinity KD=10 uM
Affinity_Assay fluorescence titration
PDB_ID 2KBS
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Assembling stable hair cell tip link complex via multidentate interactions between harmonin and cadherin 23.
Release_Year 2009
PMID 19297620
DOI 10.1073/pnas.0901819106