PPIRE08471
Target Protein Information
| Protein_Name | Sorting nexin-27 |
|---|---|
| Protein_Sequence | MADEDGEGIHPSAPHRNGGGGGGGGSGLHCAGNGGGGGGGPRVVRIVKSESGYGFNVRGQVSEGGQLRSINGELYAPLQHVSAVLPGGAADRAGVRKGDRILEVNHVNVEGATHKQVVDLIRAGEKELILTVLSVPPHEADNLDPSDDSLGQSFYDYTEKQAVPISVPRYKHVEQNGEKFVVYNVYMAGRQLCSKRYREFAILHQNLKREFANFTFPRLPGKWPFSLSEQQLDARRRGLEEYLEKVCSIRVIGESDIMQEFLSESDENYNGVSDVELRVALPDGTTVTVRVKKNSTTDQVYQAIAAKVGMDSTTVNYFALFEVISHSFVRKLAPNEFPHKLYIQNYTSAVPGTCLTIRKWLFTTEEEILLNDNDLAVTYFFHQAVDDVKKGYIKAEEKSYQLQKLYEQRKMVMYLNMLRTCEGYNEIIFPHCACDSRRKGHVITAISITHFKLHACTEEGQLENQVIAFEWDEMQRWDTDEEGMAFCFEYARGEKKPRWVKIFTPYFNYMHECFERVFCELKWRKENIFQMARSQQRDVAT |
| Organism_Source | Homo sapiens |
| Functional_Classification | PDZ-domain-containing adaptor |
| Cellular_Localization | Cytoplasm |
| Gene_Names | SNX27 |
| UniProt_ID | Q96L92 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | beta2AR-pS(?6)PDZbm + VPS26 |
|---|---|
| Peptide_Sequence | GpSSGDSLL |
| Peptide_Length | 9 |
| Peptide_SMILES | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)CN)C(=O)O |
| Chemical_Modification | S2=phosphoserine |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 831.88 |
|---|---|
| Aliphatic_Index | 86.66667 |
| Aromaticity | 0.00000 |
| Average_Rotatable_Bonds | 2.77778 |
| Charge_at_pH_7 | -1.00157 |
| Isoelectric_Point | 3.74999 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 14 |
| Number_of_Hydrogen_Bond_Donors | 13 |
| Topological_Polar_Surface_Area | 385.32000 |
| X_logP_energy | -6.41050 |
Interaction Information
| Affinity | KD=17 uM |
|---|---|
| Affinity_Assay | Isothermal titration calorimetry |
| PDB_ID | None |
| Type | Affinity ligand |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | A molecular code for endosomal recycling of phosphorylated cargos by the SNX27-retromer complex. |
| Release_Year | 2016 |
| PMID | 27595347 |
| DOI | 10.1038/nsmb.3290 |