PPIRE08481
Target Protein Information
| Protein_Name | Protein unc-119 homolog A |
|---|---|
| Protein_Sequence | MKVKKGGGGAGTATESAPGPSGQSVAPIPQPPAESESGSESEPDAGPGPRPGPLQRKQPIGPEDVLGLQRITGDYLCSPEENIYKIDFVRFKIRDMDSGTVLFEIKKPPVSERLPINRRDLDPNAGRFVRYQFTPAFLRLRQVGATVEFTVGDKPVNNFRMIERHYFRNQLLKSFDFHFGFCIPSSKNTCEHIYDFPPLSEELISEMIRHPYETQSDSFYFVDDRLVMHNKADYSYSGTP |
| Organism_Source | Homo sapiens |
| Functional_Classification | lipid transporters |
| Cellular_Localization | Cytoplasm |
| Gene_Names | UNC119 |
| UniProt_ID | Q13432 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | NPHP3 |
|---|---|
| Peptide_Sequence | GTASSLVSP |
| Peptide_Length | 9 |
| Peptide_SMILES | CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)O)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)O)C(C)C |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Myristoylation |
| C-terminal_Modification | fluorescein |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 817.89 |
|---|---|
| Aliphatic_Index | 86.66667 |
| Aromaticity | 0.00000 |
| Average_Rotatable_Bonds | 2.55556 |
| Charge_at_pH_7 | -0.00202 |
| Isoelectric_Point | 6.10000 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 14 |
| Number_of_Hydrogen_Bond_Donors | 13 |
| Topological_Polar_Surface_Area | 368.25000 |
| X_logP_energy | -6.50600 |
Interaction Information
| Affinity | KD=0.043 nM |
|---|---|
| Affinity_Assay | Fluorescence Polarization |
| PDB_ID | 5L7K |
| Type | Affinity ligand |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Novel Biochemical and Structural Insights into the Interaction of Myristoylated Cargo with Unc119 Protein and Their Release by Arl2/3. |
| Release_Year | 2016 |
| PMID | 27481943 |
| DOI | 10.1074/jbc.M116.741827 |