PPIRE08495

Target Protein Information
Protein_Name Estrogen receptor
Protein_Sequence MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV
Organism_Source Homo sapiens
Functional_Classification nuclear receptors
Cellular_Localization Nucleus
Gene_Names ESR1
UniProt_ID P03372
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name His-Lys-Ile-Lys-His-Arg-Leu-Leu-Gln
Peptide_Sequence HKIKHRLLQ
Peptide_Length 9
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1172.44
Aliphatic_Index 130.00000
Aromaticity 0.00000
Average_Rotatable_Bonds 4.66667
Charge_at_pH_7 3.17921
Isoelectric_Point 11.82307
Number_of_Hydrogen_Bond_Acceptors 16
Number_of_Hydrogen_Bond_Donors 18
Topological_Polar_Surface_Area 510.51000
X_logP_energy -2.86663
Interaction Information
Affinity KD=118 nM
Affinity_Assay Not reported
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Development of cell-permeable peptide-based PROTACs targeting estrogen receptor Alpha.
Release_Year 2020
PMID 31865016
DOI 10.1016/j.ejmech.2019.111967