PPIRE08520

Target Protein Information
Protein_Name HLA class I histocompatibility antigen, B alpha chain
Protein_Sequence MLVMAPRTVLLLLSAALALTETWAGSHSMRYFYTSVSRPGRGEPRFISVGYVDDTQFVRFDSDAASPREEPRAPWIEQEGPEYWDRNTQIYKAQAQTDRESLRNLRGYYNQSEAGSHTLQSMYGCDVGPDGRLLRGHDQYAYDGKDYIALNEDLRSWTAADTAAQITQRKWEAAREAEQRRAYLEGECVEWLRRYLENGKDKLERADPPKTHVTHHPISDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDRTFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRWEPSSQSTVPIVGIVAGLAVLAVVVIGAVVAAVMCRRKSSGGKGGSYSQAACSDSAQGSDVSLTA
Organism_Source Homo sapiens
Functional_Classification MHC class I
Cellular_Localization Plasma membrane
Gene_Names HLA-B
UniProt_ID P01889
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Pol448-9
Peptide_Sequence IPLTEEAEL
Peptide_Length 9
Peptide_SMILES CC[C@H](C)[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1014.14
Aliphatic_Index 141.11111
Aromaticity 0.00000
Average_Rotatable_Bonds 3.55556
Charge_at_pH_7 -2.99669
Isoelectric_Point 3.47280
Number_of_Hydrogen_Bond_Acceptors 14
Number_of_Hydrogen_Bond_Donors 13
Topological_Polar_Surface_Area 419.46000
X_logP_energy -2.08370
Interaction Information
Affinity KD=0.27 uM
Affinity_Assay Surface plasmon resonance
PDB_ID 5XOT
Type Agonist
Structure
Reference Information
Document_Type Research Articles
Title Conserved VDelte1 Binding Geometry in a Setting of Locus-Disparate pHLA Recognition by Delte/AlphaBeta T Cell Receptors (TCRs): Insight into Recognition of HIV Peptides by TCRs.
Release_Year 2017
PMID 28615212
DOI 10.1128/JVI.00725-17