PPIRE08529

Target Protein Information
Protein_Name Speckle-type POZ protein
Protein_Sequence MSRVPSPPPPAEMSSGPVAESWCYTQIKVVKFSYMWTINNFSFCREEMGEVIKSSTFSSGANDKLKWCLRVNPKGLDEESKDYLSLYLLLVSCPKSEVRAKFKFSILNAKGEETKAMESQRAYRFVQGKDWGFKKFIRRDFLLDEANGLLPDDKLTLFCEVSVVQDSVNISGQNTMNMVKVPECRLADELGGLWENSRFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVEPEVFKEMMCFIYTGKAPNLDKMADDLLAAADKYALERLKVMCEDALCSNLSVENAAEILILADLHSADQLKTQAVDFINYHASDVLETSGWKSMVVSHPHLVAEAYRSLASAQCPFLGPPRKRLKQS
Organism_Source Homo sapiens
Functional_Classification E3 ubiquitin-protein ligase
Cellular_Localization Nucleus
Gene_Names SPOP
UniProt_ID O43791
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name BRD3(residues 245-253)
Peptide_Sequence KADTTTPTT
Peptide_Length 9
Peptide_SMILES C[C@H](NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 935.00
Aliphatic_Index 11.11111
Aromaticity 0.00000
Average_Rotatable_Bonds 3.00000
Charge_at_pH_7 -0.00186
Isoelectric_Point 6.33737
Number_of_Hydrogen_Bond_Acceptors 17
Number_of_Hydrogen_Bond_Donors 16
Topological_Polar_Surface_Area 451.80000
X_logP_energy -7.68950
Interaction Information
Affinity KD=168 uM
Affinity_Assay Isothermal titration calorimetry
PDB_ID 6I41
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Structural Insights into BET Client Recognition of Endometrial and Prostate Cancer-Associated SPOP Mutants.
Release_Year 2019
PMID 31026449
DOI 10.1016/j.jmb.2019.04.017