PPIRE08547

Target Protein Information
Protein_Name TNF receptor-associated factor 6
Protein_Sequence MSLLNCENSCGSSQSESDCCVAMASSCSAVTKDDSVGGTASTGNLSSSFMEEIQGYDVEFDPPLESKYECPICLMALREAVQTPCGHRFCKACIIKSIRDAGHKCPVDNEILLENQLFPDNFAKREILSLMVKCPNEGCLHKMELRHLEDHQAHCEFALMDCPQCQRPFQKFHINIHILKDCPRRQVSCDNCAASMAFEDKEIHDQNCPLANVICEYCNTILIREQMPNHYDLDCPTAPIPCTFSTFGCHEKMQRNHLARHLQENTQSHMRMLAQAVHSLSVIPDSGYISEVRNFQETIHQLEGRLVRQDHQIRELTAKMETQSMYVSELKRTIRTLEDKVAEIEAQQCNGIYIWKIGNFGMHLKCQEEEKPVVIHSPGFYTGKPGYKLCMRLHLQLPTAQRCANYISLFVHTMQGEYDSHLPWPFQGTIRLTILDQSEAPVRQNHEEIMDAKPELLAFQRPTIPRNPKGFGYVTFMHLEALRQRTFIKDDTLLVRCEVSTRFDMGSLRREGFQPRSTDAGV
Organism_Source Homo sapiens
Functional_Classification ubiquitin ligases
Cellular_Localization Cytoplasm
Gene_Names TRAF6
UniProt_ID Q9Y4K3
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name CD40 peptide
Peptide_Sequence KQEPQEIDF
Peptide_Length 9
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Acetyl
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1133.22
Aliphatic_Index 43.33333
Aromaticity 0.11111
Average_Rotatable_Bonds 4.22222
Charge_at_pH_7 -1.99831
Isoelectric_Point 3.92755
Number_of_Hydrogen_Bond_Acceptors 16
Number_of_Hydrogen_Bond_Donors 15
Topological_Polar_Surface_Area 511.43000
X_logP_energy -4.06400
Interaction Information
Affinity KD=84 uM
Affinity_Assay Isothermal titration calorimetry
PDB_ID 1LB6
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Distinct molecular mechanism for initiating TRAF6 signalling.
Release_Year 2002
PMID 12140561
DOI 10.1038/nature00888