PPIRE08585
Target Protein Information
| Protein_Name | Killer cell immunoglobulin-like receptor 2DS2 |
|---|---|
| Protein_Sequence | MSLMVVSMACVGFFLLQGAWPHEGVHRKPSLLAHPGPLVKSEETVILQCWSDVRFEHFLLHREGKYKDTLHLIGEHHDGVSKANFSIGPMMQDLAGTYRCYGSVTHSPYQLSAPSDPLDIVITGLYEKPSLSAQPGPTVLAGESVTLSCSSRSSYDMYHLSREGEAHERRFSAGPKVNGTFQADFPLGPATHGGTYRCFGSFRDSPYEWSNSSDPLLVSVTGNPSNSWPSPTEPSSKTGNPRHLHVLIGTSVVKIPFTILLFFLLHRWCSNKKNAAVMDQEPAGNRTVNSEDSDEQDHQEVSYA |
| Organism_Source | Homo sapiens |
| Functional_Classification | killer cell immunoglobulin-like receptors |
| Cellular_Localization | Plasma membrane |
| Gene_Names | KIR2DS2 |
| UniProt_ID | P43631 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | Vaccinia virion membrane protein A14-derived peptide MLIYSMWGK |
|---|---|
| Peptide_Sequence | MLIYSMWGK |
| Peptide_Length | 9 |
| Peptide_SMILES | CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1128.41 |
|---|---|
| Aliphatic_Index | 86.66667 |
| Aromaticity | 0.22222 |
| Average_Rotatable_Bonds | 4.00000 |
| Charge_at_pH_7 | 0.99684 |
| Isoelectric_Point | 9.29830 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 15 |
| Number_of_Hydrogen_Bond_Donors | 14 |
| Topological_Polar_Surface_Area | 378.39000 |
| X_logP_energy | 0.30010 |
Interaction Information
| Affinity | KD=22 uM |
|---|---|
| Affinity_Assay | Surface plasmon resonance |
| PDB_ID | 4N8V |
| Type | Affinity ligand |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Activating killer cell immunoglobulin-like receptor 2DS2 binds to HLA-A*11. |
| Release_Year | 2014 |
| PMID | 24550293 |
| DOI | 10.1073/pnas.1322052111 |