PPIRE08610

Target Protein Information
Protein_Name Ribonucleoside-diphosphate reductase subunit M2
Protein_Sequence MFSVRVPLATITDQQQLQVSPLKALSLADKENTPPSLSATPVLASKVARRILQDVAEPESKVSTNPSVEDEPLLRENPRRFVVFPIEYHDIWKMYKKAEASFWTAEEVDLSKDIQHWEALKPDERHFISHVLAFFAASDGIVNENLVERFSQEVQVTEARCFYGFQIAMENIHSEMYSLLIDTYIKDSKEREYLFNAIETMPCVKKKADWALRWIGDKEATYGERVVAFAAVEGIFFSGSFASIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFKHLVHKPSEQRVQEIITNAVRIEQEFLTEALPVKLIGMNCTLMKQYIEFVADRLMLELGFNKIFKVENPFDFMENISLEGKTNFFEKRVGEYQRMGVMSNSFTLDADF
Organism_Source Mesocricetus auratus
Functional_Classification oxidoreductases
Cellular_Localization Cytoplasm
Gene_Names RRM2
UniProt_ID Q60561
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Human nonapeptide
Peptide_Sequence NSFTLDADF
Peptide_Length 9
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)[C@@H](C)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1029.07
Aliphatic_Index 54.44444
Aromaticity 0.22222
Average_Rotatable_Bonds 3.44444
Charge_at_pH_7 -2.00112
Isoelectric_Point 3.49188
Number_of_Hydrogen_Bond_Acceptors 15
Number_of_Hydrogen_Bond_Donors 15
Topological_Polar_Surface_Area 454.27000
X_logP_energy -4.97400
Interaction Information
Affinity IC50=120 pM
Affinity_Assay Enzyme Inhibition Kinetics
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Specific inhibition of ribonucleotide reductases by peptides corresponding to the C-terminal of their second subunit.
Release_Year 1991
PMID 2043345
DOI 10.1139/o91-011