PPIRE08615
Target Protein Information
| Protein_Name | Integrin beta |
|---|---|
| Protein_Sequence | MARALCLLHALWLLEWVQLLLGPGAAPPTWALNLDPVHLTIYTGPNGSHFGFSLDFYKKSHGSVSIVVGAPRTLGRNLEETGGVFLCPWKAKSVQCVALSFNLDDETRNVGAQTFQTFKARQGLGASVLTWRDNVVACAPWQHWNVLEKNEEAEKTPVGGCFVAQLQNSGRAEFSPCRANLLSLVYVESKFNDRRYCEVGFSSAVTQAGELVLGAPGGYYFLGLMARAPIADIISSYRPGTLLWHVPTQKLTFDSDLPEYYESYLGYSVAVGEFDRNPNTTEYILGGPTWSMTLGAVEIFTSKHQRLHLLQGEQVASYFGHSVAVTDVNGDGRHDLLVGAPLYMESRADHKLAEVGRVYLFLQSRGHHSLGTPSLLLTGTQLYGRFGSAIAPLGDLNRDGYNDVAVAAPYGGPTGQGQVSVFLGQSEGLNSQPSQVLHSPFAAGSAFGFSLRGATDIDDNGYPDLLVGAYGADKVVVYRAQPVVTATVQLMVQESLNPAVKNCVQPQTKTPVSCFTIQMCVGATGHNIPEKLRLNAELQLDRQKPHQSRRVLLLASQQASTVLDVDLTWRQSPTCHNTTAFLRDEADFRDKLSPIVLSFNVSLQPEKNGDALTFMLHGDTHVQEQTRIILDCGEDQVCVPKLQLSANTTGSPLLVGADNVLELHVVAANEGEGAHEAELVVHLPPGAHYMQALSNTKSFERLICTQKKENETKVVLCELGNPMKGDTQIEITMLVSVGNLEEAGEHVSFRLQIRSKNSQNPNSETVVLDVQVRAEAHLELRGNSFPASLLMAAEGDWENSSDNLGPKVEHTYELHNNGPSTVSGLHLRLHLPGQSQTSDLLYIVDIQTQGGLQCSPQPSPNPRQLDWGLHSPTPSPVYPAHHKRNRRQAVLPGQKQPSSLQDPILLSCDSAPCTVVHCDLPEMARGQRAMVTAQAFLWLPSLRQRPLDQFVLRSHAWFNVSSLPYAVPALSLPSGEAQVQTQVLRVLEDREVPLWWMLVGVLGGLLLLTLLVLAMWKCGFFKRNRPPLEESDEEEE/MRARPLWAAVLVVGALAGVGVGGPNICATRGVSSCQQCLAVSPMCAWCSDEDLPLGTPRCNLEENLLNDHCNPKYIEFPISEARILEARPLSDKGSGDSSQITQVSPQRILLRLRPDDSKSFSVQVRQVEDYPVDIYYLMDLSFSMKDDLESIQNLGTKLASQMRKLTSNLRIGFGAFVDKPVSPYMYISPPQALKNPCYDMKTTCLPMFGYKHVLTLTDQVTRFNEEVKKQNVSRNRDAPEGGFDAIMQATVCDEKIGWRNDASHLLVFTTDAKTHIALDGRLAGIVQPNDGQCHVGSDNHYSASTTMDYPSLGLITEKLSQKNINLIFAVTEGVVSLYQNYSELIPGTTVGVLSSNSSNVLQLIVDAYGKIRSKVELEVRDLPEELSLSFNATCLNNEVIPGLKSCVGLKIGDTVSFSIEAKVRGCPREKEKSFTIKPVGFKDSLTVQVTFNCDCDCQAQAEPDSPRCNNGNGTFECGVCHCGPGWLGFQCECSEKDYRPSQQDECSPQQGQPICSQRGECLCGQCVCHSSDFGKITGKYCECDDFSCVHYKGEMCSGHGQCSCGDCLCDSDWTGFYCNCTTRTDTCLSSNGLLCSGRGNCECGSCVCIQPGSYGDTCEKCPTCPDACTFKKGCVECKKFNRGSLYEANTCNRYCRDEIESVKELQDSGKNAVNCTYKNEDDCVVRFQYYEDSSGKSILYVVEEPECPKGPDILVVLLSVMGAILLIGLATLLIWKLLITIHDRKEFAKFEEERARAKWDTANNPLYKEATSTFTNITYRGT |
| Organism_Source | Sus scrofa/Sus scrofa |
| Functional_Classification | integrin |
| Cellular_Localization | Plasma membrane |
| Gene_Names | ITGA2B/ITGB3 |
| UniProt_ID | F1RQY8/Q95JH1 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | cAng51 |
|---|---|
| Peptide_Sequence | CPRGDMPC |
| Peptide_Length | 8 |
| Peptide_SMILES | CSCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CS)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CS)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | side chain-side chain cyclization; C1<->C8; disulfide bond |
| Linear/Cyclic | Cyclic |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
|
|
|
Peptide Physicochemical
| Molecular_Weight | 878.05 |
|---|---|
| Aliphatic_Index | 0.00000 |
| Aromaticity | 0.00000 |
| Average_Rotatable_Bonds | 3.00000 |
| Charge_at_pH_7 | -0.12552 |
| Isoelectric_Point | 6.06458 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 14 |
| Number_of_Hydrogen_Bond_Donors | 13 |
| Topological_Polar_Surface_Area | 348.64000 |
| X_logP_energy | -4.21363 |
Interaction Information
| Affinity | IC50=2.58 uM |
|---|---|
| Affinity_Assay | ELISA |
| PDB_ID | None |
| Type | Inhibitor |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Effect of amino acids near the RGD sequence on binding activities between AlphaIIbBeta3 integrin and fibrinogen in the presence of RGD-containing synthetic peptides from elegantin and angustatin. |
| Release_Year | 2017 |
| PMID | 28887046 |
| DOI | 10.1016/j.peptides.2017.09.004 |