PPIRE08624

Target Protein Information
Protein_Name Tumor susceptibility gene 101 protein
Protein_Sequence MAVSESQLKKMVSKYKYRDLTVRETVNVITLYKDLKPVLDSYVFNDGSSRELMNLTGTIPVPYRGNTYNIPICLWLLDTYPYNPPICFVKPTSSMTIKTGKHVDANGKIYLPYLHEWKHPQSDLLGLIQVMIVVFGDEPPVFSRPISASYPPYQATGPPNTSYMPGMPGGISPYPSGYPPNPSGYPGCPYPPGGPYPATTSSQYPSQPPVTTVGPSRDGTISEDTIRASLISAVSDKLRWRMKEEMDRAQAELNALKRTEEDLKKGHQKLEEMVTRLDQEVAEVDKNIELLKKKDEELSSALEKMENQSENNDIDEVIIPTAPLYKQILNLYAEENAIEDTIFYLGEALRRGVIDLDVFLKHVRLLSRKQFQLRALMQKARKTAGLSDLY
Organism_Source Homo sapiens
Functional_Classification endosomal sorting proteins
Cellular_Localization Cytoplasm
Gene_Names TSG101
UniProt_ID Q99816
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name peptide6
Peptide_Sequence PEXTAPPEE
Peptide_Length 9
Peptide_SMILES C[C@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]1CCCN1)[C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)O
Chemical_Modification X3=polycyclic aryl-oxime
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 925.95
Aliphatic_Index 11.11111
Aromaticity 0.00000
Average_Rotatable_Bonds 2.77778
Charge_at_pH_7 -2.99669
Isoelectric_Point 3.47280
Number_of_Hydrogen_Bond_Acceptors 14
Number_of_Hydrogen_Bond_Donors 12
Topological_Polar_Surface_Area 396.68000
X_logP_energy -4.65970
Interaction Information
Affinity KD=12 uM
Affinity_Assay Surface plasmon resonance
PDB_ID None
Type antagonist
Structure
Reference Information
Document_Type Research Articles
Title Elucidation of New Binding Interactions with the Tumor Susceptibility Gene 101 (Tsg101)Protein Using Modified HIV-1 Gag-p6 Derived Peptide Ligands.
Release_Year 2011
PMID 21643473
DOI 10.1021/ml1002579