PPIRE08649

Target Protein Information
Protein_Name Tumor susceptibility gene 101 protein
Protein_Sequence MAVSESQLKKMVSKYKYRDLTVRETVNVITLYKDLKPVLDSYVFNDGSSRELMNLTGTIPVPYRGNTYNIPICLWLLDTYPYNPPICFVKPTSSMTIKTGKHVDANGKIYLPYLHEWKHPQSDLLGLIQVMIVVFGDEPPVFSRPISASYPPYQATGPPNTSYMPGMPGGISPYPSGYPPNPSGYPGCPYPPGGPYPATTSSQYPSQPPVTTVGPSRDGTISEDTIRASLISAVSDKLRWRMKEEMDRAQAELNALKRTEEDLKKGHQKLEEMVTRLDQEVAEVDKNIELLKKKDEELSSALEKMENQSENNDIDEVIIPTAPLYKQILNLYAEENAIEDTIFYLGEALRRGVIDLDVFLKHVRLLSRKQFQLRALMQKARKTAGLSDLY
Organism_Source Homo sapiens
Functional_Classification ubiquitin E2 variant
Cellular_Localization Cytoplasm
Gene_Names TSG101
UniProt_ID Q99816
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Hrs PSAP nonapeptide
Peptide_Sequence PTPSAPVPL
Peptide_Length 9
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H]1CCCN1)[C@@H](C)O)C(C)C)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 878.04
Aliphatic_Index 86.66667
Aromaticity 0.00000
Average_Rotatable_Bonds 2.11111
Charge_at_pH_7 -0.00202
Isoelectric_Point 6.10000
Number_of_Hydrogen_Bond_Acceptors 12
Number_of_Hydrogen_Bond_Donors 9
Topological_Polar_Surface_Area 296.22000
X_logP_energy -2.68490
Interaction Information
Affinity KD=290 mM
Affinity_Assay Isothermal titration calorimetry
PDB_ID 3OBS
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Crystallographic and functional analysis of the ESCRT-I /HIV-1 Gag PTAP interaction.
Release_Year 2010
PMID 21070952
DOI 10.1016/j.str.2010.08.010