PPIRE08698

Target Protein Information
Protein_Name Cellular tumor antigen p53
Protein_Sequence MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGPDEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELPPGSTKRALPNNTSSSPQPKKKPLDGEYFTLQIRGRERFEMFRELNEALELKDAQAGKEPGGSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDSD
Organism_Source Homo sapiens
Functional_Classification tumor suppressor proteins
Cellular_Localization Nucleus
Gene_Names TP53
UniProt_ID P04637
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name biotinylated CDB3
Peptide_Sequence REDEDEIEW
Peptide_Length 9
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Biotin
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1220.21
Aliphatic_Index 43.33333
Aromaticity 0.11111
Average_Rotatable_Bonds 4.55556
Charge_at_pH_7 -4.99403
Isoelectric_Point 3.56007
Number_of_Hydrogen_Bond_Acceptors 17
Number_of_Hydrogen_Bond_Donors 20
Topological_Polar_Surface_Area 597.61000
X_logP_energy -4.28133
Interaction Information
Affinity KD=200 nM
Affinity_Assay Surface plasmon resonance
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title A peptide that binds and stabilizes p53 core domain: chaperone strategy for rescue of oncogenic mutants.
Release_Year 2002
PMID 11782540
DOI 10.1073/pnas.241629998