PPIRE08891

Target Protein Information
Protein_Name HLA class I histocompatibility antigen, alpha chain E
Protein_Sequence MVDGTLLLLLSEALALTQTWAGSHSLKYFHTSVSRPGRGEPRFISVGYVDDTQFVRFDNDAASPRMVPRAPWMEQEGSEYWDRETRSARDTAQIFRVNLRTLRGYYNQSEAGSHTLQWMHGCELGPDGRFLRGYEQFAYDGKDYLTLNEDLRSWTAVDTAAQISEQKSNDASEAEHQRAYLEDTCVEWLHKYLEKGKETLLHLEPPKTHVTHHPISDHEATLRCWALGFYPAEITLTWQQDGEGHTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPVTLRWKPASQPTIPIVGIIAGLVLLGSVVSGAVVAAVIWRKKSSGGKGGSYSKAEWSDSAQGSESHSL
Organism_Source Homo sapiens
Functional_Classification MHC class I
Cellular_Localization Plasma membrane
Gene_Names HLA-E
UniProt_ID P13747
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name HLA-G*01 leader peptide
Peptide_Sequence VMAPRTLFL
Peptide_Length 9
Peptide_SMILES CSCC[C@H](NC(=O)[C@@H](N)C(C)C)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1047.32
Aliphatic_Index 130.00000
Aromaticity 0.11111
Average_Rotatable_Bonds 3.44444
Charge_at_pH_7 0.99798
Isoelectric_Point 10.55000
Number_of_Hydrogen_Bond_Acceptors 13
Number_of_Hydrogen_Bond_Donors 13
Topological_Polar_Surface_Area 369.46000
X_logP_energy -0.80913
Interaction Information
Affinity KD=1 uM
Affinity_Assay Surface plasmon resonance
PDB_ID 3BZE
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Subtle changes in peptide conformation profoundly affect recognition of the non-classical MHC class I molecule HLA-E by the CD94-NKG2 natural killer cell receptors.
Release_Year 2008
PMID 18339401
DOI 10.1016/j.jmb.2008.01.098