PPIRE08893

Target Protein Information
Protein_Name HLA class I histocompatibility antigen, alpha chain E
Protein_Sequence MVDGTLLLLLSEALALTQTWAGSHSLKYFHTSVSRPGRGEPRFISVGYVDDTQFVRFDNDAASPRMVPRAPWMEQEGSEYWDRETRSARDTAQIFRVNLRTLRGYYNQSEAGSHTLQWMHGCELGPDGRFLRGYEQFAYDGKDYLTLNEDLRSWTAVDTAAQISEQKSNDASEAEHQRAYLEDTCVEWLHKYLEKGKETLLHLEPPKTHVTHHPISDHEATLRCWALGFYPAEITLTWQQDGEGHTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPVTLRWKPASQPTIPIVGIIAGLVLLGSVVSGAVVAAVIWRKKSSGGKGGSYSKAEWSDSAQGSESHSL
Organism_Source Homo sapiens
Functional_Classification Major histocompatibility complex class Ib
Cellular_Localization Plasma membrane
Gene_Names HLA-E
UniProt_ID P13747
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name LIL peptide
Peptide_Sequence VMAPRTLIL
Peptide_Length 9
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@@H](N)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1013.31
Aliphatic_Index 173.33333
Aromaticity 0.00000
Average_Rotatable_Bonds 3.44444
Charge_at_pH_7 0.99798
Isoelectric_Point 10.55000
Number_of_Hydrogen_Bond_Acceptors 13
Number_of_Hydrogen_Bond_Donors 13
Topological_Polar_Surface_Area 369.46000
X_logP_energy -1.00573
Interaction Information
Affinity KD=26.7 uM
Affinity_Assay Surface plasmon resonance
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title A conserved energetic footprint underpins recognition of human leukocyte antigen-E by two distinct AlphaBeta T cell receptors.
Release_Year 2017
PMID 28972140
DOI 10.1074/jbc.M117.807719