PPIRE08900
Target Protein Information
| Protein_Name | NKG2-C type II integral membrane protein |
|---|---|
| Protein_Sequence | MNKQRGTFSEVSLAQDPKRQQRKPKGNKSSISGTEQEIFQVELNLQNPSLNHQGIDKIYDCQGLLPPPEKLTAEVLGIICIVLMATVLKTIVLIPFLEQNNFSPNTRTQKARHCGHCPEEWITYSNSCYYIGKERRTWEESLLACTSKNSSLLSIDNEEEMKFLASILPSSWIGVFRNSSHHPWVTINGLAFKHKIKDSDNAELNCAVLQVNRLKSAQCGSSMIYHCKHKL |
| Organism_Source | Homo sapiens |
| Functional_Classification | C-type lectin-like receptors |
| Cellular_Localization | Plasma membrane |
| Gene_Names | KLRC2 |
| UniProt_ID | P26717 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | HLA-B*27 leader peptide |
|---|---|
| Peptide_Sequence | VTAPRTLLL |
| Peptide_Length | 9 |
| Peptide_SMILES | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)[C@@H](C)O)[C@@H](C)O)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 983.22 |
|---|---|
| Aliphatic_Index | 173.33333 |
| Aromaticity | 0.00000 |
| Average_Rotatable_Bonds | 3.22222 |
| Charge_at_pH_7 | 0.99798 |
| Isoelectric_Point | 10.55000 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 13 |
| Number_of_Hydrogen_Bond_Donors | 14 |
| Topological_Polar_Surface_Area | 389.69000 |
| X_logP_energy | -2.37803 |
Interaction Information
| Affinity | KD=12.9 uM |
|---|---|
| Affinity_Assay | Surface plasmon resonance |
| PDB_ID | 3CII |
| Type | Affinity ligand |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Structural basis for NKG2A/CD94 recognition of HLA-E. |
| Release_Year | 2008 |
| PMID | 18448674 |
| DOI | 10.1073/pnas.0802736105 |